{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:30:58Z","timestamp":1787509858755,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS111166"],"award-info":[{"award-number":["R01NS111166"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to characterize the neurodevelopment and risk factors for impairment at age 5 to 6\u2009years after acute provoked neonatal seizures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multicenter study of neonates with acute provoked seizures. Wechsler Preschool and Primary Scale of Intelligence IV (WPPSI\u2010IV), Vineland\u20103 Adaptive Behavior Scales, Behavior Assessment System for Children, Behavior Rating Inventory of Executive Function, Social Responsiveness Scale, cerebral palsy (CP), and epilepsy were assessed at age 5 to 6\u2009years. Latent class analysis defined outcome profiles. Least absolute shrinkage and selection operator (LASSO) was used to determine outcome predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We characterized 3 latent classes among 164 children: (1) Typical Development (63%); (2) Behavioral Dysregulation (13%; low likelihood of physical impairment or severely impaired cognition, high likelihood of attention deficit hyperactivity disorder [ADHD]); and (3) Multi\u2010Domain Impairment (24%; high likelihood of epilepsy and impairment across all domains). Among 144 children with standardized testing, mean WPPSI\u2010IV was 91\u2009\u00b1\u200925 and Vineland\u20103 Adaptive Behavior Composite 90\u2009\u00b1\u200920. Twenty\u2010nine percent had ADHD or elevated attention\/hyperactivity scores; 19% had autism or elevated Social Responsiveness scores; 20% had epilepsy, and 19% had CP. Risk factors for Multi\u2010Domain Impairment were abnormal neonatal neurologic examination (odds ratio [OR]\u2009=\u20093.94, 95% confidence interval [CI]\u2009=\u20091.74\u20138.95), impaired functional development at age 24\u2009months (OR\u2009=\u20093.82, 95% CI\u2009=\u20091.25\u201311.66), and CP (OR\u2009=\u20093.71, 95% CI\u2009=\u20091.74\u20137.90). No neonatal or infant characteristics were significantly associated with Behavioral Dysregulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Nearly two\u2010thirds of 5 to 6\u2010year\u2010old children with provoked neonatal seizures had typical development. Yet, executive and behavioral dysregulation were prevalent, even with preserved cognitive and physical function. These findings can inform outcome discussions and interventions to promote neurodevelopment. ANN NEUROL 2026;99:777\u2013791<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.78100","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T10:42:46Z","timestamp":1767436966000},"page":"777-791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Profiles and Predictors of Neurodevelopmental Outcome at 5\u20136\u2009Years in Children With a History of Acute Provoked Neonatal Seizures"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3879-1966","authenticated-orcid":false,"given":"Hannah C.","family":"Glass","sequence":"first","affiliation":[{"name":"Department of Neurology and Weill Institute for Neuroscience University of California San Francisco  San Francisco CA USA"},{"name":"Department of Pediatrics, UCSF Benioff Children's Hospital University of California San Francisco  San Francisco CA USA"},{"name":"Department of Epidemiology &amp; Biostatistics University of California San Francisco  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1594-9812","authenticated-orcid":false,"given":"Adam L.","family":"Numis","sequence":"additional","affiliation":[{"name":"Department of Neurology and Weill Institute for Neuroscience University of California San Francisco  San Francisco CA USA"},{"name":"Department of Pediatrics, UCSF Benioff Children's Hospital University of California San Francisco  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6998-7753","authenticated-orcid":false,"given":"Janet S.","family":"Soul","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children's Hospital, Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney J.","family":"Wusthoff","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California Davis Health  Sacramento CA USA"},{"name":"Department of Pediatrics \u2010 Division of Neonatal and Developmental Medicine Stanford University  Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6253-775X","authenticated-orcid":false,"given":"Monica E.","family":"Lemmon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Population Health Sciences Duke University School of Medicine  Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia M.","family":"Benedetti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics C. 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Mott Children's Hospital and the University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine J.","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital, Harvard Medical School  Boston MA USA"},{"name":"Department of Neurology Kennedy Krieger Institute, Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shavonne L.","family":"Massey","sequence":"additional","affiliation":[{"name":"Department of Neurology and Pediatrics Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Cincinnati College of Medicine Division of Neurology, Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1686-8352","authenticated-orcid":false,"given":"Tayyba","family":"Anwar","sequence":"additional","affiliation":[{"name":"Department of Neurology and Pediatrics Children's National Hospital and The George Washington University School of Medicine  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Sturza","sequence":"additional","affiliation":[{"name":"Department of Pediatrics C. 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Mott Children's Hospital and the University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2469-1518","authenticated-orcid":false,"given":"Madison M.","family":"Berl","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Children's Research Institute, Children's National Hospital George Washington University  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging University of California San Francisco  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth E.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UCSF Benioff Children's Hospital University of California San Francisco  San Francisco CA 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