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We are moving from conventional parallel\u2010group randomized controlled trials (RCTs) to other designs, such as n\u2010of\u20101 trials. Historically, inclusion criteria for antiseizure medicine (ASM) RCTs have stipulated a minimum number of seizures in the baseline period to judge ASM efficacy. For Dravet syndrome, RCTs have demanded 4 or more seizures\/month in the baseline period. However, only 25% of children have sufficiently frequent seizures to qualify for RCTs. Trial outcomes should be tailored to the disease and long\u2010term issues for patients, a much broader remit than seizure frequency alone. 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