{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:09:33Z","timestamp":1791983373256,"version":"4.4.0"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The evidence regarding adherence to dietary patterns and Parkinson's disease (PD) risk is inconsistent. Because of the long prodromal PD phase, reverse causation represents a major threat to investigations of diet in relation to PD. We examined whether adherence to the Mediterranean (MED) and Mediterranean\u2010Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diets is associated with PD incidence, while considering reverse causation, in a large cohort of women with a 25\u2010year follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants from the E3N (Etude Epid\u00e9miologique aupr\u00e8s des femmes de la Mutuelle G\u00e9n\u00e9rale de l\u2019Education Nationale) study were prospectively followed\u2010up from 1993 to 2018. PD diagnoses were validated using medical records and drug claim databases. Baseline MED and MIND scores were computed using a validated food questionnaire. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using multivariable Cox regression models. Exposures were lagged by 5\u2009years in main analyses and longer lags in sensitivity analyses. We performed age\u2010stratified analyses and adjusted for prodromal symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Analyses (5\u2010year\u2013lag) are based on 71,542 women (845 PD patients). Higher adherence to MED and MIND diets was not associated with PD overall, but was associated with lower PD incidence in women &lt;71 years old (MED, HR\n                      <jats:sub>high vs. low+medium<\/jats:sub>\n                      \u2009=\u20090.76 [0.58\u20131.00],\n                      <jats:italic>p<\/jats:italic>\n                      \u2010Age \u00d7 MED\u2009interaction =\u20090.038; MIND, HR\n                      <jats:sub>high vs. low+medium<\/jats:sub>\n                      \u2009=\u20090.75 [0.58\u20130.97],\n                      <jats:italic>p<\/jats:italic>\n                      \u2010Age \u00d7 MIND\u2009interaction =\u20090.035). Legumes and high unsaturated to saturated fat ratio had the strongest contribution for the MED diet, while beans and olive oil had the strongest contribution for the MIND diet. Results were consistent after adjustment for constipation\/depression and in analyses with lags up to 20\u2009years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Adherence to the MED and MIND diets was associated with lower PD incidence &lt;71\u2009years in women. These findings are important for planning preventative interventions. ANN NEUROL 2026;99:1014\u20131029<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.78115","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T11:17:34Z","timestamp":1767698254000},"page":"1014-1029","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Adherence to the Mediterranean and Mediterranean\u2010Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (\n                    <scp>MIND<\/scp>\n                    ) Diets and Parkinson's Disease Incidence in Women: Results from the Prospective\n                    <scp>E3N<\/scp>\n                    Cohort"],"prefix":"10.1002","volume":"99","author":[{"given":"Mariem","family":"Hajji\u2010Louati","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, UVSQ, Inserm, Gustave Roussy, CESP  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Correia","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, UVSQ, Inserm, Gustave Roussy, CESP  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Chen","family":"Lee","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, UVSQ, Inserm, Gustave Roussy, CESP  Villejuif France"},{"name":"Department of Public Health College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Artaud","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, UVSQ, Inserm, Gustave Roussy, CESP  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Roze","sequence":"additional","affiliation":[{"name":"Neurology Department AP\u2010HP, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"},{"name":"Sorbonne Universit\u00e9  Paris France"},{"name":"INSERM U1127, CNRS 7225, Brain Institute  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca Romana","family":"Mancini","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, UVSQ, Inserm, Gustave Roussy, CESP  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9724-5490","authenticated-orcid":false,"given":"Alexis","family":"Elbaz","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, UVSQ, Inserm, Gustave Roussy, CESP  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200793"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.10.379"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-024-00681-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11081896"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2016.07.001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.4243"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojpm.2015.55023"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.26736B"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200202000-00002"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-024-01036-9"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.5.1486"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13113970"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28314"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnha.2024.100451"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu184"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-022-00851-y"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.6.1214"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/26.suppl_1.S128"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-277X.1995.tb00296.x"},{"key":"e_1_2_9_21_1","unstructured":"ANSES.Ciqual: Table de composition nutritionnelle des aliments 2017. 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