{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:40:28Z","timestamp":1787841628409,"version":"build-2784847793"},"reference-count":66,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Traumatic brain injury (TBI) is an established risk factor for dementia, although the underlying mechanisms remain unclear. Our previous research demonstrated that a single severe TBI in wild\u2010type (WT) mice induces a prion\u2010like form of tau (tau\n                      <jats:sup>TBI<\/jats:sup>\n                      ) that spreads throughout the brain, leading to memory deficits. Here, we investigated whether similar self\u2010propagating tau\n                      <jats:sup>TBI<\/jats:sup>\n                      conformers are generated in humans after severe TBI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We biochemically assessed tau and phosphorylated tau (P\u2010tau) levels in human brain contusions surgically removed acutely after severe TBI. Inoculation studies were performed using human TBI brain homogenates in WT and tau knockout (KO) mice to investigate the role of endogenous tau in tau\n                      <jats:sup>TBI<\/jats:sup>\n                      propagation. Cognitive function was evaluated using the novel object recognition test, the radial arm water maze, and the Y\u2010maze. Pathological changes in the brain of the inoculated mice were analyzed by histological and biochemical analyses, and targeted transcriptomics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Inoculation of human TBI brain homogenates in WT mice caused widespread tau deposition and cognitive impairment, hippocampal synaptic loss, and disease\u2010associated transcriptomic changes. Effects were similar upon secondary inoculation in WT but not tau KO mice, confirming a tau\u2010dependent mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>\n                      Severe TBI induces transmissible tau\n                      <jats:sup>TBI<\/jats:sup>\n                      conformers in humans acutely after injury, potentially exacerbating post\u2010traumatic pathology, and increasing the risk for dementia later in life. ANN NEUROL 2026;99:897\u2013911\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.78132","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T06:57:26Z","timestamp":1767164246000},"page":"897-911","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Human Brain Contusions Contain Pathogenic Transmissible Species that Induce Progressive Cognitive Decline and Tau Pathology in Mice"],"prefix":"10.1002","volume":"99","author":[{"given":"Gloria","family":"Vegliante","sequence":"first","affiliation":[{"name":"Laboratory of Traumatic Brain Injury and Neuroprotection, Department of Acute Brain and Cardiovascular Injury Istituto di Ricerche Farmacologiche Mario Negri IRCCS  Milan Italy"},{"name":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute Trinity College  Dublin 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