{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T05:36:49Z","timestamp":1777095409539,"version":"3.51.4"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Naturally occurring autoantibodies are commonly considered to be causative of autoimmune diseases or epiphenomena with no known biological impact. Although clinically beneficial autoantibodies have been described, there have been no naturally occurring anti\u2010neuronal antibodies that have been found to be neuroprotective. Here, we identify a recombinant human antibody (TGM\u2010010) derived from a patient with multiple sclerosis (MS) that binds human and mouse neurons, leading to beneficial effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>TGM\u2010010 was examined for its ability to be internalized by human and mouse neurons and protect neurons from death in vitro following a stress event. TGM\u2010010 was also injected systemically into a relapsing\u2013remitting model of experimental autoimmune encephalomyelitis (EAE) to examine its ability to impact disease score, extent of demyelination, and neuron frequency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>TGM\u2010010 demonstrates many novel characteristics including crossing the blood\u2010brain barrier (BBB) and internalizing into neurons. TGM\u2010010 also protects primary mouse neurons from death in vitro. In a mouse model of MS, TGM\u2010010 ameliorates disease severity and is associated with improved neuronal survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>This study identified a patient\u2010derived neuron\u2010binding autoantibody that crosses the BBB in mice and reduces neuron loss in a mouse model of MS. These data suggest that the human derived anti\u2010neuronal antibody, TGM\u2010010, may potentially be used to ameliorate neurodegeneration that underlies disability in neurodegenerative conditions. ANN NEUROL 2026;99:1152\u20131165<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.78149","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T08:00:39Z","timestamp":1768032039000},"page":"1152-1165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Patient\u2010Derived Antibody Ameliorates Disease Severity in a Relapsing Remitting Murine Model of Multiple Sclerosis"],"prefix":"10.1002","volume":"99","author":[{"given":"Chad","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Neurology The University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin M.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Department of Neurology The University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"O'Donnell Brain Institute, The University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Neurology The University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Mosavi\u2010Hecht","sequence":"additional","affiliation":[{"name":"Department of Neurology The University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Semedo\u2010Kuriki","sequence":"additional","affiliation":[{"name":"Department of Neurology The University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Benavides","sequence":"additional","affiliation":[{"name":"Department of Neurology The University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology The University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yipin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology The University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Neurology The University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5686-0315","authenticated-orcid":false,"given":"Bret M.","family":"Evers","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiel M.","family":"Telesford","sequence":"additional","affiliation":[{"name":"Department of Neurology The University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"Department of Ophthalmology and Visual Sciences Vanderbilt University  Nashville Texas USA"},{"name":"Department of Neurology Vanderbilt University  Nashville Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel G.","family":"Yanev","sequence":"additional","affiliation":[{"name":"Department of Neurology The University of Kentucky  Lexington Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Mettlen","sequence":"additional","affiliation":[{"name":"Department of Cell Biology The University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann M.","family":"Stowe","sequence":"additional","affiliation":[{"name":"Department of Neurology The University of Kentucky  Lexington Texas USA"},{"name":"Department of Neuroscience The University of Kentucky  Lexington Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doug","family":"Kerr","sequence":"additional","affiliation":[{"name":"GenrAb, Inc.  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