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This randomized, placebo\u2010controlled, double\u2010blinded study aimed to assess the effects of fecal microbiota transplantation (\n FMT<\/jats:styled-content>\n ) on the manifestation of the motor symptoms of\n PD<\/jats:styled-content>\n (The Movement Disorders Society \u2010 Unified Parkinson's Disease Rating Scale Part III [MDS\u2010UPDRS III]) over a 12\u2009month long observation and non\u2010motor symptoms as secondary objectives: the Movement Disorders Society\u2010Non\u2010Motor Rating Scale;\n EuroQol<\/jats:styled-content>\n \u20105 Dimension;\n PD<\/jats:styled-content>\n Quality\u2010of\u2010Life Questionnaire; Montreal Cognitive Assessment (\n MoCA<\/jats:styled-content>\n );\n UPDRS<\/jats:styled-content>\n I,\n II<\/jats:styled-content>\n , and\n IV<\/jats:styled-content>\n ; Gastrointestinal Dysfunction Scale for\n PD<\/jats:styled-content>\n ; modified Constipation Assessment Scale; and levodopa equivalent dose.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The patients were randomly assigned to receive either fecal microbiota (Mbiotix, Human Biome Institute) or placebo (auto\u2010fecal microbiota, prepared from the patient's stool) in a 1:1 ratio. The fecal microbiota transplantation was performed via colonoscopy. Assessments were performed before and after 12\u2009months for the MoCA and at 1, 3, 6, and 12\u2009months for the other scales. Intention\u2010to\u2010treat analysis was performed using a multivariable mixed regression model.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 59 patients included, 28 were randomly assigned to the Mbiotix group (median age\u2009=\u200965\u2009years; 15 male patients) and 31 to the placebo group (median age\u2009=\u200963\u2009years; 14 male patients). No significant differences were observed in the MDS\u2010UPDRS III \u201cOFF\u201d state score at 12\u2009months between groups (1.50 points, 95% confidence interval [CI]\u2009=\u2009\u22124.28 to 7.28,\n p<\/jats:italic>\n \u2009=\u20091.00), however, some non\u2010motor symptoms improved in different study timepoints.\n <\/jats:p>\n <\/jats:sec>\n \n Interpretation<\/jats:title>\n A single FMT does not influence motor symptoms manifestation in patients with PD but could improve non\u2010motor functioning via gut\u2010brain axis.<\/jats:p>\n \n Trial registration information:<\/jats:bold>\n Clinical Trial ID NCT05204641 was submitted on November 29, 2021. The first patient was enrolled on January 4, 2022. 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