{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:07:17Z","timestamp":1792130837490,"version":"4.4.0"},"reference-count":179,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>As the population ages, certain neurodegenerative diseases (NDs) are becoming a major health issue. For this reason, this review will focus on the most common ND with onset after 65\u2009years old; Alzheimer's disease, Parkinson's disease, Lewy body dementia, and frontotemporal dementia. NDs are the results of multifactorial processes causing pleiotropic changes in molecular and protein networks linking a host of biological processes that lead to protein dysregulation and aggregation that ultimately leads to neurodegeneration. Genetic, transcriptomic, and proteomic studies have been instrumental to identify novel genes and proteins implicated on diseases that point to novel disease mechanism, as well as the identification of disease biomarkers. Here, we provide a review of the genomic, transcriptomic, and proteomic studies on ND so far, as well as future opportunities and challenges. ANN NEUROL 2026;99:566\u2013587<\/jats:p>","DOI":"10.1002\/ana.78170","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T10:19:06Z","timestamp":1770200346000},"page":"566-587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Understanding Neurodegenerative Diseases From the \u2212Omics Perspective: Lessons Learnt"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2381-7059","authenticated-orcid":false,"given":"Laura","family":"Ibanez","sequence":"first","affiliation":[{"name":"Department of Psychiatry Washington University in St. Louis School of Medicine  St. Louis MO USA"},{"name":"NeuroGenomics and Informatics Center Washington University in St. Louis School of Medicine  St. Louis MO USA"},{"name":"Department of Neurology Washington University in St. Louis School of Medicine  St. Louis MO USA"},{"name":"Hope Center for Neurological Disorders Washington University in St. Louis School of Medicine  St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Pottier","sequence":"additional","affiliation":[{"name":"NeuroGenomics and Informatics Center Washington University in St. Louis School of Medicine  St. Louis MO USA"},{"name":"Department of Neurology Washington University in St. Louis School of Medicine  St. Louis MO USA"},{"name":"The Charles F. and Joanne Knight Alzheimer Disease Research Center Washington University in St. Louis  St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Beric","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University in St. Louis School of Medicine  St. Louis MO USA"},{"name":"NeuroGenomics and Informatics Center Washington University in St. Louis School of Medicine  St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Western","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University in St. Louis School of Medicine  St. Louis MO USA"},{"name":"NeuroGenomics and Informatics Center Washington University in St. Louis School of Medicine  St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University in St. Louis School of Medicine  St. Louis MO USA"},{"name":"NeuroGenomics and Informatics Center Washington University in St. Louis School of Medicine  St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0276-2899","authenticated-orcid":false,"given":"Carlos","family":"Cruchaga","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University in St. Louis School of Medicine  St. Louis MO USA"},{"name":"NeuroGenomics and Informatics Center Washington University in St. Louis School of Medicine  St. Louis MO USA"},{"name":"Department of Neurology Washington University in St. Louis School of Medicine  St. Louis MO USA"},{"name":"Hope Center for Neurological Disorders Washington University in St. Louis School of Medicine  St. Louis MO USA"},{"name":"The Charles F. and Joanne Knight Alzheimer Disease Research Center Washington University in St. Louis  St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01024-z"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30320-5"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00785-3"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30400-3"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2024.05.017"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70065-1"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.536"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.11.036"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXG.0000000000000177"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.06.008"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.01.014"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01208-7"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211103"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211851"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-023-00687-4"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu277"},{"key":"e_1_2_12_18_1","first-page":"1567","article-title":"TREM2 and neurodegenerative disease","volume":"369","author":"Benitez BA","year":"2013","journal-title":"N Engl J Med"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.08.016"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2308-7"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1016"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1436-x"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade2044"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70237"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28494"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-5-r52"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-018-0001-7"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090278"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1718"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.226"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.225672.117"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1841-z"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-0879-z"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1027"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu067"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12825"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14221"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.11.005"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70377"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13370"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12350"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11283"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106140"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24969"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0611-3"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02318-3"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2010.08.018"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00089"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12187"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.108534"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-022-00288-w"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-016-0355-3"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0219-3"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-01175-9"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.03.030"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389202918666171005100549"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2020.13"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab437"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105225"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160520"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-5-45"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14683"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900830R"},{"key":"e_1_2_12_64_1","first-page":"8885","article-title":"LncRNA NEAT1 promotes Alzheimer's disease by down regulating micro\u201027a\u20103p","volume":"13","author":"Dong LX","year":"2021","journal-title":"Am J Transl Res"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-020-00656-8"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.00090"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1836-12.2012"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1230436"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114089"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes7120116"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.04.023"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2020.03.017"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0501-5"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23084134"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-019-02066-0"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.038"},{"key":"e_1_2_12_77_1","doi-asserted-by":"crossref","unstructured":"MiyoshiE MorabitoS HenningfieldCM et al.Spatial and single\u2010nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's disease. bioRxiv 2023.","DOI":"10.1002\/alz.075878"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-021-02343-x"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.018"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0695-9"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-019-0524-x"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07871-6"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07606-7"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.037"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.02.009"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1177\/25424823241307878"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-021-00088-6"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12880"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39652-6"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2011.02.016"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb1654"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-024-00839-3"},{"key":"e_1_2_12_93_1","doi-asserted-by":"crossref","unstructured":"BericA Cisterna\u2010GarciaA MartinC et al.Plasma acellular transcriptome contains Parkinson's disease signatures that can inform clinical diagnosis. medRxiv 2024.","DOI":"10.1101\/2024.10.18.24315717"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42004-025-01665-1"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-01113-5"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42004-025-01753-2"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2023.100557"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm5164"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06592-6"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42834-x"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14413"},{"key":"e_1_2_12_102_1","doi-asserted-by":"crossref","unstructured":"DouglasY KirsherSC PhongA et al.The current landscape of plasma proteomics: technical advances biological insights and biomarker discovery. bioRxiv 2025.","DOI":"10.1101\/2025.02.14.638375"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06563-x"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2025.02.014"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-025-00872-8"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-023-00638-z"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-024-01737-w"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz9360"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.12.032"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2024.1379717"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2019.12.002"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-021-00064-0"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-023-00550-7"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adm9654"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-024-00749-1"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abq5923"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-021-00886-6"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-021-00999-y"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-024-02706-0"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-56293-z"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-022-00524-0"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00065-9"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170834"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-024-01972-8"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.06.010"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01588-0"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11091361"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae035"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12050739"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-023-00565-0"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12369"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00606-8"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38719-8"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2021.797833"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.04.012"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01907-0"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03833-1"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004383"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34408"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3506"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz1776"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00913-z"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-023-01300-6"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00976-y"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf3041"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00801-6"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01128-z"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-024-01896-3"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00978-w"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj1541"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202216359"},{"key":"e_1_2_12_153_1","first-page":"44","article-title":"Genome\u2010wide quantitative trait loci mapping of the human cerebrospinal fluid proteome","volume":"26","author":"Sasayama D","year":"2017","journal-title":"Hum Mol Genet"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-023-00461-9"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-024-01972-8"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2021.01.012"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02509-y"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-023-00555-4"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau2291"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-00773-z"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.801"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXG.0000000000000571"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1533-5"},{"key":"e_1_2_12_164_1","doi-asserted-by":"crossref","unstructured":"OhleiO SommererY DobricicV et al.Genome\u2010wide QTL mapping across three tissues highlights several Alzheimer's and Parkinson's disease loci potentially acting via DNA methylation. medRxiv 2023 2023.12.22.23300365.","DOI":"10.1101\/2023.12.22.23300365"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00969-x"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adh4265"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-024-01973-7"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-01583-z"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.12.044"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2021.07.017"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02869-z"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0781-z"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14414"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.08.049"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-025-00882-5"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41122-y"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1274268"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2022.100661"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2025.105844"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.78170","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ana.78170","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.78170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:36:42Z","timestamp":1772984202000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.78170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,4]]},"references-count":179,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/ana.78170"],"URL":"https:\/\/doi.org\/10.1002\/ana.78170","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,4]]},"assertion":[{"value":"2025-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}