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Plasma P\u2010tau217 is a sensitive biomarker for amyloid and tau pathology in Alzheimer's disease. The objective was to determine if plasma P\u2010tau217 associates with Alzheimer's disease co\u2010pathology and cognition in Lewy body disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants had (1) a clinicopathological diagnosis of Parkinson's disease or dementia with Lewy bodies in the pathology series, or (2) a clinical diagnosis of Parkinson's disease in the clinical series and were followed as part of the longitudinal, observational cohort study at the University of Pennsylvania between 2007 and 2024. Plasma concentration of P\u2010tau217 was measured in previously collected samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Neuropathology cases included 46 Parkinson's disease and 10 dementia with Lewy bodies, and clinical cases included 173 Parkinson's disease, and 64 controls. P\u2010tau217 was greater in cases with (median, 0.3 [interquartile range (IQR), 0.2\u20130.4]) versus without (median, 0.1 [IQR, 0.1\u20130.2]) Alzheimer's disease co\u2010pathology (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and discriminates Lewy body disorders participants with Alzheimer's disease co\u2010pathology (area under curve, 0.84). Parkinson's disease participants with incident cognitive impairment had greater increases in serial P\u2010tau217 than those who remained cognitively stable (group \u00d7 time interaction \u03b2\u2009=\u2009\u22120.010,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0027). Higher baseline P\u2010tau217 concentrations associated with longitudinal change in dementia rating scale (group \u00d7 time interaction \u03b2\u2009=\u2009\u22124.947,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0166) and higher risk for cognitive progression (hazard ratio\u2009=\u20091.597,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Plasma P\u2010tau217 detects Alzheimer's disease co\u2010pathology in Lewy body disorders and predicts cognitive decline. Future studies will evaluate associations between plasma P\u2010tau217 and imaging and clinical outcomes, in consideration for use of amyloid\u2010targeting therapies in Lewy body disorders. ANN NEUROL 2026;99:1428\u20131437<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.78201","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T12:48:28Z","timestamp":1773838108000},"page":"1428-1437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association between Plasma P\u2010tau217 and Alzheimer's Copathology and Cognitive Decline in Parkinson's Disease"],"prefix":"10.1002","volume":"99","author":[{"given":"Thomas F.","family":"Tropea","sequence":"first","affiliation":[{"name":"Department of Neurology University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Aldea","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Flitter","sequence":"additional","affiliation":[{"name":"Eli Lilly 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