{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T05:04:17Z","timestamp":1776834257072,"version":"3.51.2"},"reference-count":8,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"abstract":"<jats:p>In the 15\u2009years since Parkinson's Progression Markers Initiative (PPMI) launched, research conduct has advanced with broader connectivity, enabling virtual and hybrid methods for recruitment, engagement, education, and data collection. To meet evolving needs, PPMI created \u201cmyPPMI,\u201d which has grown from an informational portal to a multi\u2010country, participant\u2010centered, virtual research environment integrating education, screening, e\u2010consent, longitudinal non\u2010motor and motor assessments, and biospecimen referral. Built on a secure, cloud\u2010native architecture with daily analytics and a multi\u2010tier support model, myPPMI enables precision recruitment, real\u2010time eligibility matching, and standardized low\u2010burden data capture across studies. The platform is designed to enable focused data collection from individuals or groups based on the data they have already provided. This strategy provides the tools to establish precise subsets of high interest that could be targeted for further data acquisition. Usability testing and rapid global scaling demonstrate a generalizable, decentralized framework for biomarker\u2010driven, Parkinson's disease research. ANN NEUROL 2026<\/jats:p>","DOI":"10.1002\/ana.78230","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T04:25:52Z","timestamp":1776831952000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Developing a Virtual Research Environment in the Parkinson's Progression Markers Initiative:\n                    <scp>myPPMI<\/scp>"],"prefix":"10.1002","author":[{"suffix":"Jr","given":"Craig E.","family":"Stanley","sequence":"first","affiliation":[{"name":"Institute for Neurodegenerative Disorders  New Haven CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Fabrizio","sequence":"additional","affiliation":[{"name":"Institute for Neurodegenerative Disorders  New Haven CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bridget A.","family":"McMahon","sequence":"additional","affiliation":[{"name":"Institute for Neurodegenerative Disorders  New Haven CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Auldyn","family":"Matthews\u2010McGee","sequence":"additional","affiliation":[{"name":"Institute for Neurodegenerative Disorders  New Haven CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cailey","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Institute for Neurodegenerative Disorders  New Haven CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeina","family":"Singh","sequence":"additional","affiliation":[{"name":"Institute for Neurodegenerative Disorders  New Haven CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nichole H.","family":"Rigby","sequence":"additional","affiliation":[{"name":"Institute for Neurodegenerative Disorders  New Haven CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John\u2010Michael","family":"Talarico","sequence":"additional","affiliation":[{"name":"Institute for Neurodegenerative Disorders  New Haven CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9744-8562","authenticated-orcid":false,"given":"Ethan G.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Neurology, Weill Institute for Neurosciences University of California  San Francisco CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Korell","sequence":"additional","affiliation":[{"name":"Department of Neurology, Weill Institute for Neurosciences University of California  San Francisco CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maggie","family":"McGuire Kuhl","sequence":"additional","affiliation":[{"name":"The Michael J. Fox Foundation for Parkinson's Research  New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Destro","sequence":"additional","affiliation":[{"name":"The Michael J. Fox Foundation for Parkinson's Research  New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Pavese","sequence":"additional","affiliation":[{"name":"Clinical Ageing Research Unit Newcastle University  Newcastle UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0652-6348","authenticated-orcid":false,"given":"Alicia","family":"Garrido","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Cl\u00ednic, IDIBAPS Universitat de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brit","family":"Mollenhauer","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center  Kassel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohini","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"The Michael J. Fox Foundation for Parkinson's Research  New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Marek","sequence":"additional","affiliation":[{"name":"Institute for Neurodegenerative Disorders  New Haven CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline M.","family":"Tanner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Weill Institute for Neurosciences University of California  San Francisco CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F.","family":"Tropea","sequence":"additional","affiliation":[{"name":"Institute for Neurodegenerative Disorders  New Haven CT"},{"name":"Department of Neurology University of Pennsylvania Perelman School of Medicine  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Parkinson's Progression Markers Initiative","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"e_1_2_18_2_1","doi-asserted-by":"publisher","DOI":"10.2196\/47882"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25892"},{"key":"e_1_2_18_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pdig.0001191"},{"key":"e_1_2_18_5_1","unstructured":"Vue.js: The Progressive JavaScript Framework (Version 3.x) Available at:https:\/\/vuejs.org\/. Accessed February 17 2026."},{"key":"e_1_2_18_6_1","unstructured":"Amazon Web Services.What is cloud computing?n.d. Available at:https:\/\/aws.amazon.com\/what-is-cloud-computing\/. Accessed February 17 2026."},{"key":"e_1_2_18_7_1","unstructured":"DBT: dbt Labs.dbt (Version 1.7) 2023. Available at:https:\/\/www.getdbt.com\/. Accessed February 17 2026."},{"key":"e_1_2_18_8_1","unstructured":"Google.Looker (Version 7.0) 2025. Available at:https:\/\/cloud.google.com\/looker\/. Accessed February 17 2026."},{"key":"e_1_2_18_9_1","doi-asserted-by":"publisher","DOI":"10.2196\/37290"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.78230","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ana.78230","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.78230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T04:25:57Z","timestamp":1776831957000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.78230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":8,"alternative-id":["10.1002\/ana.78230"],"URL":"https:\/\/doi.org\/10.1002\/ana.78230","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]},"assertion":[{"value":"2026-02-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ana.78230"}}