{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T22:50:15Z","timestamp":1792363815361,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Sensitive outcome measures are critical for evaluating the efficacy of novel treatments for Parkinson's disease (PD). In this study, we assess the sensitivity to change of sensor\u2010derived daily\u2010life tremor measures over 2\u2009years in unmedicated and medicated persons with early PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used 2\u2010year continuous wrist sensor data (median wear time: 22\u2009hours\/day) from the Personalized Parkinson Project (n\u2009=\u2009462 medicated; n\u2009=\u200978 unmedicated at baseline), in combination with annual clinical evaluations of tremor severity. From the gyroscope data, we derived previously validated weekly measures for tremor time and power, which were smoothed over time using piecewise linear trend estimation. One\u2010 and 2\u2010year standardized response means (SRMs) were computed to compare the sensitivity to change between the sensor\u2010derived tremor measures and clinical tremor scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In unmedicated participants with tremor, sensor\u2010derived tremor measures demonstrated a high sensitivity to progression (2\u2010year SRMs ranged from 0.67 to 1.09), which was significantly larger than clinical tremor scores (2\u2010year SRMs ranged from 0.21 to 0.41). In medicated participants, sensor\u2010derived tremor time decreased (2\u2010year SRM of \u22120.18), which was associated with both an increase in dopaminergic medication dose and higher disease duration. In contrast, the sensor\u2010derived tremor power measures and clinical rest tremor scores (measured in the OFF state) increased slightly (2\u2010year SRMs ranging from 0.11 to 0.27).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Before initiation of symptomatic treatment, sensor\u2010derived daily\u2010life tremor measures are substantially more sensitive to progression than clinical tremor scores, making them a promising tool to evaluate the efficacy of disease\u2010modifying treatments in early PD. ANN NEUROL 2026;100:282\u2013294<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.78236","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:00:22Z","timestamp":1778652022000},"page":"282-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Daily\u2010Life, Sensor\u2010Derived Tremor Measures Are Sensitive to Progression in Early Parkinson's Disease"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3814-3440","authenticated-orcid":false,"given":"Nienke A.","family":"Timmermans","sequence":"first","affiliation":[{"name":"Center of Expertise for Parkinson and Movement Disorders, Department of Neurology Donders Institute for Brain, Cognition and Behavior Radboud University Medical Center  Nijmegen The 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