{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:29:00Z","timestamp":1787840940186,"version":"build-2784847793"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The interleukin (IL)\u20101, IL\u20106, and C\u2010reactive protein (CRP) pathway is central to the immune response after intracerebral hemorrhage (ICH). We tested for associations between hematoma and plasma cytokine concentrations and patient outcomes in Minimally Invasive Surgery Plus Rt\u2010PA for ICH Evacuation Phase III (MISTIE III) participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Inflammation after minimally invasive evacuation of ICH (INFLAME)\u2010ICH was a sub\u2010study nested in MISTIE III. Daily hematoma fluid was collected from surgical patients and peripheral blood for all patients. Multiple regression models compared hematoma cytokine concentrations to the modified Rankin scale (mRS) score at 1\u2009year. Correlations between hematoma and plasma cytokine concentrations were tested. We compared plasma cytokines in patients randomized to surgery (vs medical). Gene expression in monocyte\/macrophages and neutrophils were compared in a subset of participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 89 patients were recruited (47 surgical, 42 medical). Mean hematoma IL\u20101 receptor antagonist (IL\u20101Ra) (odds ratio [OR]: 5.92; 95% confidence interval [CI]: 1.08\u201332.54; n\u2009=\u200938) and mean hematoma IL\u20106 (OR: 3.23; 95% CI: 1.33\u20137.81; n\u2009=\u200945) were independently associated with good outcome (mRS, 0\u20133) at 1\u2009year. Higher hematoma IL\u20101\u03b2 was associated with higher plasma CRP (\u03b2\u2010coefficient: 21.0; 95% CI: 4.4\u201337.5;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009117 paired samples). No differences were seen in plasma IL\u20106, CRP and IL\u20101Ra in patients by treatment group.\n                      <jats:italic>IL1B<\/jats:italic>\n                      ,\n                      <jats:italic>IL6<\/jats:italic>\n                      , and\n                      <jats:italic>IL1RN<\/jats:italic>\n                      transcripts in monocyte\/macrophages correlated with respective protein concentrations in hematoma fluid.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Hematomal IL\u20101Ra within a week of ICH is independently associated with a good outcome at 1 year, supporting further investigation of IL\u20101Ra in ICH. IL\u20106 is independently associated with a good outcome at 1 year, which might suggest a role in enhancing repair and recovery. ANN NEUROL 2026;100:345\u2013360<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.78237","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:10:34Z","timestamp":1777867834000},"page":"345-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hematoma Interleukin\u20101 Receptor Antagonist Concentrations Predict Long\u2010Term Outcome in Acute Human Intracerebral Hemorrhage"],"prefix":"10.1002","volume":"100","author":[{"given":"Adrian R.","family":"Parry\u2010Jones","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health University of Manchester  Manchester UK"},{"name":"Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust &amp; University of Manchester  Manchester 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University of Manchester  Manchester UK"},{"name":"Division of Neuroscience Faculty of Biology, Medicine and Health, University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siobhan","family":"Crilly","sequence":"additional","affiliation":[{"name":"Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust &amp; University of Manchester  Manchester UK"},{"name":"Division of Neuroscience Faculty of Biology, Medicine and Health, University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Kasher","sequence":"additional","affiliation":[{"name":"Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust &amp; University of Manchester  Manchester UK"},{"name":"Division of Neuroscience Faculty of Biology, Medicine and Health, University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Davidson","sequence":"additional","affiliation":[{"name":"Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust &amp; University of Manchester  Manchester UK"},{"name":"Division of Neuroscience Faculty of Biology, Medicine and Health, University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Roncaroli","sequence":"additional","affiliation":[{"name":"Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust &amp; University of Manchester  Manchester UK"},{"name":"Division of Neuroscience Faculty of Biology, Medicine and Health, University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart M.","family":"Allan","sequence":"additional","affiliation":[{"name":"Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust &amp; University of Manchester  Manchester UK"},{"name":"Division of Neuroscience Faculty of Biology, Medicine and Health, University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren H.","family":"Sansing","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale University School of Medicine  New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Ziai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine  Baltimore MD"},{"name":"Department of Neurology Johns Hopkins University School of Medicine  Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel 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