{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T06:09:24Z","timestamp":1778911764395,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"abstract":"<jats:p>The Parkinson's Progression Markers Initiative (PPMI) has remained at the vanguard of Parkinson's disease (PD) research through evolving recruitment strategies that mirror advances in PD biology. PPMI was initially focused on untreated, early\u2010stage PD. Over time, it has expanded to include genetic cohorts, prodromal participants identified via olfactory testing and risk factor questionnaires targeting people with rapid eye movement (REM) sleep behavior disorder (RBD). Most recently, PPMI has focused on the biology underlying PD and sought to recruit individuals defined by neuronal alpha\u2010synuclein disease (NSD) biomarkers. This evolution from clinical to biological enrollment demonstrates the feasibility of biomarker\u2010driven cohort design and establishes a scalable model for early detection and prevention research in neurodegenerative disease. ANN NEUROL 2026<\/jats:p>","DOI":"10.1002\/ana.78239","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T05:31:04Z","timestamp":1778477464000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recruitment Strategies across the Spectrum of Neuronal Synuclein Disease"],"prefix":"10.1002","author":[{"given":"Andrew","family":"Siderowf","sequence":"first","affiliation":[{"name":"Department of Neurology University of Pennsylvania Perelman School of Medicine  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura E.A.","family":"Heathers","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics Indiana University  Indianapolis IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Fabrizio","sequence":"additional","affiliation":[{"name":"Institute for Neurodegenerative Disorders  New Haven CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maggie McGuire","family":"Kuhl","sequence":"additional","affiliation":[{"name":"The Michael J. Fox Foundation for Parkinson's Research  New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine M.","family":"Kopil","sequence":"additional","affiliation":[{"name":"The Michael J. Fox Foundation for Parkinson's Research  New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Flagg","sequence":"additional","affiliation":[{"name":"Institute for Neurodegenerative Disorders  New Haven CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bridget A.","family":"McMahon","sequence":"additional","affiliation":[{"name":"Institute for Neurodegenerative Disorders  New Haven CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher S.","family":"Coffey","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Iowa  Iowa City IW"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audra","family":"Bright","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics Indiana University  Indianapolis IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Totten","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics Indiana University  Indianapolis IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynell P.","family":"Lemon","sequence":"additional","affiliation":[{"name":"Institute for Neurodegenerative Disorders  New Haven CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erinn","family":"Bryan","sequence":"additional","affiliation":[{"name":"Institute for Neurodegenerative Disorders  New Haven CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha","family":"Prakash","sequence":"additional","affiliation":[{"name":"Institute for Neurodegenerative Disorders  New Haven CT"},{"name":"XingImaging  New Haven CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Pavese","sequence":"additional","affiliation":[{"name":"Clinical Ageing Research Unit Newcastle University  Newcastle UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bastiaan R.","family":"Bloem","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre of Expertise for Parkinson and Movement Disorders Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy N.","family":"Alcalay","sequence":"additional","affiliation":[{"name":"Movement Disorders Division Neurological Institute, Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Department of Neurology Columbia University Irving Medical Center  New York NY"},{"name":"Gray Faculty of Medicine and Health Sciences and Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1520-2292","authenticated-orcid":false,"given":"Anat","family":"Mirelman","sequence":"additional","affiliation":[{"name":"Movement Disorders Division Neurological Institute, Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"Gray Faculty of Medicine and Health Sciences and Sagol School of Neuroscience Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonidas","family":"Stefanis","sequence":"additional","affiliation":[{"name":"First Department of Neurology National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Njideka","family":"Okubadejo","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Medicine, College of Medicine University of Lagos  Lagos Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Tolosa","sequence":"additional","affiliation":[{"name":"Neurology Service, Hospital Cl\u00ednic of Barcelona. Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Universidad de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline M.","family":"Tanner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Weill Institute for Neurosciences University of California  San Francisco CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2347-1644","authenticated-orcid":false,"given":"Tanya","family":"Simuni","sequence":"additional","affiliation":[{"name":"Department of Neurology Northwestern University Feinberg School of Medicine  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohini","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"The Michael J. Fox Foundation for Parkinson's Research  New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F.","family":"Tropea","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pennsylvania Perelman School of Medicine  Philadelphia PA"},{"name":"Institute for Neurodegenerative Disorders  New Haven CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Marek","sequence":"additional","affiliation":[{"name":"Institute for Neurodegenerative Disorders  New Haven CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Foroud","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics Indiana University  Indianapolis IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Parkinson's Progression Markers Initiative","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00109-6"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00405-2"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.09.005"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.644"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000277648.63931.c0"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.10207"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1809983"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.151"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(84)90269-5"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-025-00809-0"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21740"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25037"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28139"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.27158"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.78239","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ana.78239","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.78239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T05:31:05Z","timestamp":1778909465000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.78239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,10]]},"references-count":14,"alternative-id":["10.1002\/ana.78239"],"URL":"https:\/\/doi.org\/10.1002\/ana.78239","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,10]]},"assertion":[{"value":"2026-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ana.78239"}}