{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:05:06Z","timestamp":1788822306338,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Accurately predicting future hemorrhagic events in patients with cerebral amyloid angiopathy (CAA) remains a major clinical challenge. It is unknown whether cerebrospinal fluid (CSF) biomarkers of amyloid\u2010beta (A\u03b2) pathology are associated with increased hemorrhage risk in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed consecutive patients meeting Boston criteria version 2.0 for probable CAA with CSF A\u03b2 data obtained during diagnostic workup. The primary outcome was incident intracranial hemorrhage, including lobar intracerebral, convexity subarachnoid, and non\u2010traumatic subdural hemorrhage. Secondary outcomes were ischemic stroke and all\u2010cause mortality. Associations between low CSF A\u03b2 biomarkers and outcomes were analyzed using Cox proportional hazards models, adjusted for disseminated cortical superficial siderosis, and prior intracerebral hemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 109 patients (median age: 77\u2009years, 42% female), 16 (15%) experienced incident intracranial hemorrhage and 11 (10%) incident ischemic stroke during a median follow\u2010up of 2.93\u2009years (interquartile range: 1.43\u20135.03). In multivariate Cox regression models low CSF A\u03b2 biomarkers were independently associated with incident intracranial hemorrhage (A\u03b2\n                      <jats:sub>40<\/jats:sub>\n                      : hazard ratio: 8.04; [95% CI: 2.43\u201326.59],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      : hazard ratio 7.10; [95% CI: 1.58\u201332.00],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011). CSF A\u03b2 biomarkers were not associated with incident ischemic strokes and all\u2010cause mortality. A composite risk score integrating low CSF A\u03b2 biomarkers and hemorrhagic imaging features identified a high\u2010risk subgroup with 78% hemorrhage incidence (7\/9 patients) and a no\u2010risk group without events (0\/42 patients).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Low CSF A\u03b2 biomarkers are independently associated with future symptomatic hemorrhage in CAA patients. A composite risk score may support individualized risk stratification and guide clinical decision\u2010making. ANN NEUROL 2026;100:391\u2013399<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.78241","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T02:10:06Z","timestamp":1777342206000},"page":"391-399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cerebrospinal Fluid Amyloid\u2010\u03b2 Biomarkers Predict Future Hemorrhage in Patients with Cerebral Amyloid Angiopathy"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0517-6473","authenticated-orcid":false,"given":"Philipp","family":"Arndt","sequence":"first","affiliation":[{"name":"Department of Neurology Otto\u2010von\u2010Guericke University  Magdeburg Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) within the Helmholtz Association  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Pfister","sequence":"additional","affiliation":[{"name":"Department of Neurology Otto\u2010von\u2010Guericke University  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3551-5237","authenticated-orcid":false,"given":"Valentina","family":"Perosa","sequence":"additional","affiliation":[{"name":"J. Philip Kistler Stroke Research Center, Massachusetts General Hospital\/Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Mattern","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) within the Helmholtz Association  Magdeburg Germany"},{"name":"Biomedical Magnetic Resonance, Faculty of Natural Sciences Otto\u2010von\u2010Guericke University  Magdeburg Germany"},{"name":"Center for Behavioral Brain Sciences  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melis","family":"Tas","sequence":"additional","affiliation":[{"name":"Department of Neurology Otto\u2010von\u2010Guericke University  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Holzheimer","sequence":"additional","affiliation":[{"name":"Department of Neurology Otto\u2010von\u2010Guericke University  Magdeburg 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