{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T11:26:07Z","timestamp":1788607567940,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1AG075922"],"award-info":[{"award-number":["RF1AG075922"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG085320"],"award-info":[{"award-number":["R01AG085320"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS097723"],"award-info":[{"award-number":["R01NS097723"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 CA186107"],"award-info":[{"award-number":["UM1 CA186107"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    We conducted a nested case\u2010control study within the Nurses\u2019 Health Study and the Health Professionals Follow\u2010up Study to examine the role of the gut virome (GV) in Parkinson's disease (PD). We applied a novel metagenomic virome profiling approach, Bioinformatic Application for Quantification and Labeling of Viral taxonomy (BAQLaVa), to prospectively collected metagenomic data from 62 participants with PD, 123 healthy controls, and 90 participants with prodromal PD (pPD). Multivariate linear modeling identified 3 viral genome bins (VGBs) that were elevated in PD: MVG081219 (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.86,\n                    <jats:italic>q<\/jats:italic>\n                    \u2009=\u20090.013), MVG041501 (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.95,\n                    <jats:italic>q<\/jats:italic>\n                    \u2009=\u20090.048), MVG081211 (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.66,\n                    <jats:italic>q<\/jats:italic>\n                    \u2009=\u20090.048) and one VGB, MVG098915 (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009= \u22121.42,\n                    <jats:italic>q<\/jats:italic>\n                    \u2009=\u20090.047) that was depleted in participants with PD compared to controls. These four VGBs were similarly associated with pPD. This work suggests that the GV has potential as a future biomarker for PD. ANN NEUROL 2026;100:334\u2013340\n                  <\/jats:p>","DOI":"10.1002\/ana.78243","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T04:26:46Z","timestamp":1779942406000},"page":"334-340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Shotgun Metagenomic Profiling of the Gut Virome in Prodromal and Confirmed Parkinson's Disease"],"prefix":"10.1002","volume":"100","author":[{"given":"Deepika","family":"Dinesh","sequence":"first","affiliation":[{"name":"Department of Public Health University of Massachusetts Lowell  Lowell MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xochitl C.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Harvard T. H. Chan School of Public Health  Boston MA"},{"name":"Harvard Chan Microbiome in Public Health Center (HCMPH) Harvard T. H. Chan School of Public Health  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Jensen","sequence":"additional","affiliation":[{"name":"Harvard Chan Microbiome in Public Health Center (HCMPH) Harvard T. H. Chan School of Public Health  Boston MA"},{"name":"Department of Immunology and Infectious Diseases Harvard T. H. Chan School of Public Health  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2892-6986","authenticated-orcid":false,"given":"Kjetil","family":"Bjornevik","sequence":"additional","affiliation":[{"name":"Department of Nutrition Harvard T. H. Chan School of Public Health  Boston MA"},{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital and Harvard Medical School  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Schwarzschild","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Ascherio","sequence":"additional","affiliation":[{"name":"Department of Nutrition Harvard T. H. Chan School of Public Health  Boston MA"},{"name":"Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital and Harvard Medical School  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis","family":"Huttenhower","sequence":"additional","affiliation":[{"name":"Harvard Chan Microbiome in Public Health Center (HCMPH) Harvard T. H. Chan School of Public Health  Boston MA"},{"name":"Department of Immunology and Infectious Diseases Harvard T. H. Chan School of Public Health  Boston MA"},{"name":"Broad Institute of MIT and Harvard  Cambridge MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0643-7735","authenticated-orcid":false,"given":"Natalia","family":"Palacios","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Massachusetts Lowell  Lowell MA"},{"name":"Department of Veterans Affairs ENRM VA Hospital  Bedford MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26719"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.12.029"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/NS20170166"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13333"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.01.018"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.30"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2235"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.68.3.560-602.2004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1305923110"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29173-4"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-017-0283-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1319470110"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-318275"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.08.003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm098"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-018-0176-y"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3002083"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1009442"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1300833110"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.01.017"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa025039"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.78243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ana.78243","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.78243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:33:23Z","timestamp":1787837603000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.78243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,27]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/ana.78243"],"URL":"https:\/\/doi.org\/10.1002\/ana.78243","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,27]]},"assertion":[{"value":"2025-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}