{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:42:21Z","timestamp":1792658541142,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"S38","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>The creation and ongoing development of the myPPMI platform (see Stanley et al in this issue), has enabled the Parkinson's Progression Markers Initiative (PPMI) to expand our research efforts to acquire additional data, engage a large number of participants, and reduce participant burden to enable long\u2010term follow\u2010up. We now review specific virtual and remote studies and sub\u2010studies including Found, PPMI Online, and PPMI Cognitive that PPMI has developed to enhance participant engagement and enable remote data collection. FOUND in PPMI was initiated before myPPMI and continues to serve as a model for remote participant engagement. FOUND maintains longitudinal contact, reducing study attrition, and preserving data continuity. PPMI Online, now part of myPPMI, enables low\u2010burden, participant\u2010reported data collection, reduces geographic barriers, and enables sub\u2010studies of less common subgroups. Cognitive testing is another study within myPPMI to assess longitudinal cognition. myPPMI, a global web\u2010based portal, introduces precision recruitment, real\u2010time eligibility matching, and inclusive design. Together, these innovations enable remote and hybrid recruitment and study conduct, reduce logistical and economic barriers, and advance scalable, participant\u2010centered research to transform the landscape of Parkinson's disease studies across populations. ANN NEUROL 2026;100:S80\u2013S87<\/jats:p>","DOI":"10.1002\/ana.78245","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T05:26:43Z","timestamp":1778477203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Expanding\n                    <scp>PPMI<\/scp>\n                    through Remote Data Acquisition and Analysis: Early Success and Future Growth with\n                    <scp>myPPMI<\/scp>"],"prefix":"10.1002","volume":"100","author":[{"given":"Caroline M.","family":"Tanner","sequence":"first","affiliation":[{"name":"Department of Neurology Weill Institute for Neurosciences, University of California  San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig E.","family":"Stanley","sequence":"additional","affiliation":[{"name":"Institute for Neurodegenerative Diseases  New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9744-8562","authenticated-orcid":false,"given":"Ethan G.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Neurology Weill Institute for Neurosciences, University of California  San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana M.","family":"Chahine","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pittsburgh  Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Weintraub","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pennsylvania Perelman School of Medicine  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roseanne D.","family":"Dobkin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Rutgers University, Robert Wood Johnson Medical School  Piscataway NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Poewe","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Tolosa","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Cl\u00ednic, IDIBAPS, Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"Marras","sequence":"additional","affiliation":[{"name":"Edmond J. 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