{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:29:36Z","timestamp":1787840976743,"version":"build-2784847793"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to quantify incremental diagnostic yield and prognostic value of continuous electroencephalography (cEEG; \u226512\u2009hours) versus a 60\u2010minute short electroencephalography (sEEG) in predicting post\u2010stroke epilepsy (PSE) in patients without acute symptomatic seizures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively included 283 adults who underwent cEEG within 7\u2009days; sEEG comprised the first 60\u2009minutes of the same recording. EEGs were interpreted using American Clinical Neurophysiology Society (ACNS) terminology by neurophysiologists blinded to outcomes. Within\u2010patient yield was quantified using odds ratios (ORs) with 95% confidence intervals (CIs). PSE were modeled using Fine\u2013Gray competing\u2010risks regression (death as competing event) and reported as subdistribution hazard ratios (sHR). SeLECT\u2010EEG derived from sEEG and cEEG was compared using C\u2010index and net reclassification improvement (NRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over a median follow\u2010up of 41\u2009months (interquartile range [IQR] =\u200922\u201364), 41 of 283 patients (14.5%) developed PSE. Compared to sEEG, cEEG increased detection of interictal epileptiform discharges (11 vs 3%, OR\u2009=\u20093.75, 95% CI\u2009=\u20091.75\u20138.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and electrographic seizures (4 vs 0.7%, OR\u2009=\u20096.22, 95% CI\u2009=\u20091.38\u201328.06,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). Lateralized periodic discharges (sHR\u2009=\u20094.50, 95% CI\u2009=\u20092.13\u20139.51) and electrographic seizures (sHR\u2009=\u20093.63, 95% CI\u2009=\u20091.52\u20138.63) were the strongest predictors of PSE. The cEEG\u2010derived SeLECT\u2010EEG improved discrimination versus sEEG\u2010derived scoring (\u0394C\u2010index 0.055, 95% CI\u2009=\u20090.012\u20130.101,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014) and reclassification (NRI\u2009=\u20090.25, 95% CI\u2009=\u20090.07\u20130.42). Epileptiform activity emerging after the first hour conferred higher 5\u2010year PSE risk than never detected (28 vs 11%, Gray\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>The cEEG identifies additional epileptiform abnormalities with prognostic value beyond routine\u2010duration EEG, supporting extension of monitoring in selected cases based on baseline risk and early EEG findings. ANN NEUROL 2026;100:400\u2013415<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.78251","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T05:44:06Z","timestamp":1779083046000},"page":"400-415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Continuous Versus Short\n                    <scp>EEG<\/scp>\n                    After Ischemic Stroke: What\n                    <scp>cEEG<\/scp>\n                    Adds for Detecting Abnormalities and Predicting Post\u2010Stroke Epilepsy"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1438-7544","authenticated-orcid":false,"given":"Kai Michael","family":"Schubert","sequence":"first","affiliation":[{"name":"Department of Neurology, Clinical Neuroscience Center University Hospital and University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya","family":"Dasari","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Cleveland Clinic  Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Tatillo","sequence":"additional","affiliation":[{"name":"Department of Neurology H\u00f4pital Universitaire de Bruxelles \u2013 H\u00f4pital Erasme  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Naeije","sequence":"additional","affiliation":[{"name":"Department of Neurology H\u00f4pital Universitaire de Bruxelles \u2013 H\u00f4pital Erasme  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6035-6581","authenticated-orcid":false,"given":"S\u00e1ndor","family":"Beniczky","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology Aarhus University Hospital, Aarhus and Danish Epilepsy Centre  Dianalund Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Bentes","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Mental Health (Neurology), Hospital de Santa Maria \u2013 ULSSM, Centro de Estudos Egas Moniz, Faculdade de Medicina Universidade de Lisboa  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2307-071X","authenticated-orcid":false,"given":"Marian","family":"Galovic","sequence":"additional","affiliation":[{"name":"Department of Neurology, Clinical Neuroscience Center University Hospital and University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Gaspard","sequence":"additional","affiliation":[{"name":"Department of Neurology H\u00f4pital Universitaire de Bruxelles \u2013 H\u00f4pital Erasme  Brussels Belgium"},{"name":"Laboratory of Experimental Neurology Universit\u00e9 Libre de Bruxelles  Brussels Belgium"},{"name":"Department of Neurology Yale University School of Medicine  New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0552-6736","authenticated-orcid":false,"given":"Vineet","family":"Punia","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Cleveland Clinic  Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)33064-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-021-00837-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209450"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30404-0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.124.050045"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.0611"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.27301"},{"key":"e_1_2_10_9_1","volume-title":"StatPearls. 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