{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:05:10Z","timestamp":1788822310189,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim was to determine whether plasma amyloid beta (A\u03b2) A\u03b237, A\u03b240, A\u03b242, and p\u2010tau217 differ in cerebral amyloid angiopathy (CAA) from controls and associate with specific magnetic resonance imaging (MRI) markers of CAA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single center hospital\u2010based study (Massachusetts General Hospital) enrolling patients with probable or definite CAA per Boston 2.0 criteria among consecutive individuals presenting with spontaneous intracerebral hemorrhage (ICH) and non\u2010acute ICH related symptoms. Control participants were identified among individuals 55\u2009years or older without history of ICH attending outpatient clinics in the same catchment area and time as the CAA cases. Primary outcome tested whether plasma A\u03b237, A\u03b240, A\u03b242, and p\u2010tau217 differ between patients with CAA and controls. Secondary outcome evaluated the correlation with the severity of selected CAA neuroradiological hallmarks on brain MRI scans obtained within 1\u2009year of sample collection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 186 patients with CAA (mean age, 71.2\u2009\u00b1\u20098.3\u2009years; males, 107 [58%]) and 401 controls (mean age, 73.9\u2009\u00b1\u20098.3\u2009years; males, 211 [53%]) were included in the study. CAA cases had lower A\u03b240 (\u03b2\u2009=\u2009\u22120.60, 95% CI = \u22120.80 to \u22120.40,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), A\u03b242 (\u03b2\u2009=\u2009\u22120.48, 95% CI = \u22120.70 to \u22120.27,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and higher p\u2010tau217 (\u03b2\u2009=\u20090.73, 95 %CI\u2009=\u20090.54 to 0.91,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) concentrations compared to controls. A\u03b240 was the only fragment reduced independent of ptau217 levels. Within the CAA group, biomarkers were associated with both hemorrhagic (reduced A\u03b242 with cortical superficial siderosis) and non\u2010hemorrhagic (reduced A\u03b240 and A\u03b242 with enlarged perivascular spaces in centrum semiovale, reduced A\u03b237 and increased p\u2010tau217 with white matter hyperintensities) MRI hallmarks of CAA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Plasma A\u03b240, A\u03b242, and p\u2010tau217 differ between CAA patients and controls and are informative on CAA severity as inferred from brain MRI markers. ANN NEUROL 2026;100:380\u2013390<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.78264","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:15:53Z","timestamp":1780546553000},"page":"380-390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Plasma Amyloid Beta and Tau Associations with Cerebral Amyloid Angiopathy Presence and Severity"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1725-1175","authenticated-orcid":false,"given":"Francesco","family":"Bax","sequence":"first","affiliation":[{"name":"J.P. 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