{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:04:49Z","timestamp":1789729489009,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2023NSCQMSX0221"],"award-info":[{"award-number":["CSTB2023NSCQMSX0221"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the safety and effectiveness of adjunctive intra\u2010arterial tenecteplase (TNK) in patients with acute ischemic stroke (AIS) due to cardioembolism (CE) and non\u2010CE who achieved near\u2010complete to complete reperfusion (defined as an expanded thrombolysis in cerebral infarction score of 2c\u20103) following endovascular treatment (EVT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prespecified secondary analysis of the POST\u2010TNK randomized, open\u2010label, blinded outcome assessment trial categorized 540 patients by stroke etiology into CE (n\u2009=\u2009272) and non\u2010CE (n\u2009=\u2009268) subgroups. The primary outcome was freedom from disability at 90\u2009days, defined as a modified Rankin Scale score of 0 to 1. Safety outcomes included 90\u2010day mortality, symptomatic intracranial hemorrhage (sICH) within 48\u2009hours, and any intracranial hemorrhage (ICH) within 48\u2009hours.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 272 patients with CE (median age, 73\u2009years [interquartile range, 66\u201378]; 47.1% male), 137 were assigned to the control group and 135 to the intra\u2010arterial TNK group. Compared with the control group, intra\u2010arterial TNK was associated with significantly higher odds of freedom from disability at 90\u2009days (adjusted odds ratio, 1.80; 95% confidence interval [CI], 1.02\u20133.16;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04; inverse probability of treatment weighting adjusted odds ratio, 1.58; 95% CI, 1.12\u20132.22;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). No significant differences were observed in 90\u2010day mortality, sICH, or any ICH within 48\u2009hours between groups. Conversely, intra\u2010arterial TNK was not associated with improved functional outcomes in patients with AIS due to non\u2010CE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>In patients with AIS due to CE who achieved near\u2010complete to complete reperfusion after EVT, adjunctive intra\u2010arterial TNK was associated with a higher likelihood of freedom from disability at 90\u2009days, without increasing the risk of mortality or ICH. However, this benefit was not observed in AIS patients due to non\u2010CE. ANN NEUROL 2026;100:841\u2013849<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.78304","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T10:58:08Z","timestamp":1786100288000},"page":"841-849","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of Intra\u2010Arterial Tenecteplase after Endovascular Reperfusion for Acute Ischemic Stroke Due to Cardioembolism and Non\u2010Cardioembolism: A Secondary Analysis of the\n                    <scp>POST<\/scp>\n                    \u2010\n                    <scp>TNK<\/scp>\n                    Trial"],"prefix":"10.1002","volume":"100","author":[{"given":"Miao","family":"Chai","sequence":"first","affiliation":[{"name":"Department of Neurology Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuexiao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chawen","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoxuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)  Chongqing China"},{"name":"Department of Neurology The 908th Hospital of Chinese People's Liberation Army Joint Logistic Support Force  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology Renhuai People's Hospital  Renhuai China"},{"name":"Department of Neurology The Affiliated Yongchuan Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)  Chongqing China"},{"name":"Department of Neurology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9227-8801","authenticated-orcid":false,"given":"Zhenqian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfu","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binghan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Neurology Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0715-198X","authenticated-orcid":false,"given":"Junjie","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Neurology Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1945-2360","authenticated-orcid":false,"given":"Jiaxing","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)  Chongqing China"},{"name":"Department of Neurology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4068-3139","authenticated-orcid":false,"given":"Gaoming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-076161"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000528922"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.124.048994"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000013210"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.124.047441"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26474"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.1645"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00519-1"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1716405"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2022.02880"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.23466"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25115777"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2018-000143"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.23523"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2020-016966"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706442"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713973"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.020315"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-025-13026-y"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.010049"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2022.101537"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14631"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.10800"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.23480"},{"key":"e_1_2_10_27_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2024-080489","article-title":"Intra\u2010arterial tenecteplase after successful endovascular recanalisation in patients with acute posterior circulation arterial occlusion (attention\u2010ia): multicentre randomised controlled trial","volume":"388","author":"Hu W","year":"2025","journal-title":"BMJ"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2024-091059"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2025.2036"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.043635"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.026299"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.043634"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2023.01578"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2024.04119"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.037411"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.78304","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ana.78304","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.78304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:30:47Z","timestamp":1789727447000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.78304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,7]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/ana.78304"],"URL":"https:\/\/doi.org\/10.1002\/ana.78304","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,7]]},"assertion":[{"value":"2026-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}