{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T23:12:46Z","timestamp":1791673966619,"version":"4.3.4"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to investigate the associations between Alzheimer's disease (AD)\u2010related blood biomarkers and changes in brain volumes and cerebrovascular burden in community\u2010dwelling older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 361 dementia\u2010free participants with a Mini\u2010Mental State Examination (MMSE) score \u2265\u200927 and without prior cerebrovascular events from a Swedish population\u2010based study. Blood phosphorylated\u2010tau217 (p\u2010tau217), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) were measured at baseline. Brain magnetic resonance imaging (MRI) was performed at baseline and after 3 and\/or 6\u2009years. Linear mixed models were used to examine associations between AD\u2010related blood biomarkers and changes in volumes of total brain tissue (TBTV), lateral ventricles, hippocampus, amygdala, and white matter hyperintensities (WMHs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the follow\u2010up, higher p\u2010tau217 was associated with faster volume loss in the hippocampus (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      *year = \u22120.047, 95% confidence interval [CI] = \u22120.077 to \u22120.018) and in the amygdala (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      *year = \u22120.064, 95% CI = \u22120.105 to \u22120.022). Elevated GFAP was linked to faster TBTV decline (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      *year = \u22120.040, 95% CI = \u22120.059 to \u22120.021), ventricular enlargement (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      *year\u2009=\u20090.028, 95% CI\u2009=\u20090.013 to 0.042), and hippocampal shrinkage (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      *year = \u22120.038, 95% CI = \u22120.064 to \u22120.013). Participants with higher NfL showed steeper TBTV decline, ventricular enlargement, hippocampal and amygdala shrinkage, and faster WMH accumulation. Results remained largely consistent after excluding participants with mild cognitive impairment at baseline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>In cognitively unimpaired older adults, elevated blood p\u2010tau217 was linked to faster shrinkage in AD\u2010specific brain regions, whereas NfL and GFAP were associated with more widespread atrophy, with NfL also associated with accelerated WMH accumulation. These findings suggest that AD\u2010related blood biomarkers may capture different dementia\u2010related structural brain changes already at early stages. ANN NEUROL 2026<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.78309","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:14:09Z","timestamp":1785215649000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Blood Biomarkers of Alzheimer's Disease and Patterns of Structural Brain Changes in the Community"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0139-8287","authenticated-orcid":false,"given":"Martina","family":"Valletta","sequence":"first","affiliation":[{"name":"Aging Research Center, Department of Neurobiology, Care Sciences and Society Karolinska Institutet and Stockholm University  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide Liborio","family":"Vetrano","sequence":"additional","affiliation":[{"name":"Aging Research Center, Department of Neurobiology, Care Sciences and Society Karolinska Institutet and Stockholm University  Stockholm Sweden"},{"name":"Stockholm Gerontology Research Center  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika J.","family":"Laukka","sequence":"additional","affiliation":[{"name":"Aging Research Center, Department of Neurobiology, Care Sciences and Society Karolinska Institutet and Stockholm University  Stockholm Sweden"},{"name":"Stockholm Gerontology Research Center  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goria","family":"Kalpouzos","sequence":"additional","affiliation":[{"name":"Aging Research Center, Department of Neurobiology, Care Sciences and Society Karolinska Institutet and Stockholm University  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Oltra","sequence":"additional","affiliation":[{"name":"Aging Research Center, Department of Neurobiology, Care Sciences and Society Karolinska Institutet and Stockholm University  Stockholm Sweden"},{"name":"Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora","family":"Rizzuto","sequence":"additional","affiliation":[{"name":"Aging Research Center, Department of Neurobiology, Care Sciences and Society Karolinska Institutet and Stockholm University  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Canevelli","sequence":"additional","affiliation":[{"name":"Aging Research Center, Department of Neurobiology, Care Sciences and Society Karolinska Institutet and Stockholm University  Stockholm Sweden"},{"name":"Department of Human Neuroscience Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Fredolini","sequence":"additional","affiliation":[{"name":"Affinity Proteomics Stockholm, Science for Life Laboratory, Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH) Royal Institute of Technology (KTH)  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxuan","family":"Qiu","sequence":"additional","affiliation":[{"name":"Aging Research Center, Department of Neurobiology, Care Sciences and Society Karolinska Institutet and Stockholm University  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Winblad","sequence":"additional","affiliation":[{"name":"Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society Karolinska Institutet  Solna Sweden"},{"name":"Theme Inflammation and Aging Karolinska University Hospital  Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Fratiglioni","sequence":"additional","affiliation":[{"name":"Aging Research Center, Department of 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