{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:40:23Z","timestamp":1792658423026,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:p>In this post hoc analysis of the ANNEXa\u2010I trial (n\u2009=\u2009434), we evaluated non\u2010contrast computed tomography (NCCT) markers of hematoma expansion (HE) in factor Xa inhibitor (FXai) \u2013associated intracerebral hemorrhage (ICH). At least one NCCT marker was present in 72.1%, and HE (\u226512.5\u2009mL or\u2009\u2265\u200935% increase in hematoma volume) occurred in 31.8%. Heterogeneous density, hypodensity, and the black hole sign were independently associated with HE. The effect of andexanet on HE was generally consistent across NCCT marker subgroups. These findings support the utility of NCCT markers for identifying patients at high risk of HE in FXai\u2010associated ICH. ANN NEUROL 2026;100:979\u2013983<\/jats:p>","DOI":"10.1002\/ana.78347","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:30:46Z","timestamp":1788870646000},"page":"979-983","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non\u2010contrast\n                    <scp>CT<\/scp>\n                    Markers of Hematoma Expansion and Andexanet Response in Factor Xa Inhibitor\u2010Associated Intracerebral Hemorrhage: An Analysis from\n                    <scp>ANNEXa<\/scp>\n                    \u2010I Trial"],"prefix":"10.1002","volume":"100","author":[{"given":"Koji","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences, Cumming School of Medicine University of Calgary  Calgary Alberta 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