{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:19:36Z","timestamp":1788445176473,"version":"build-2803163510"},"reference-count":67,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Memory impairment is a frequent comorbidity of focal epilepsy, incompletely explained by seizure frequency or structural pathology. Ictal and postictal hippocampal dysfunction disrupt memory processes, but their cumulative impact remains poorly quantified. This study introduces cumulative hippocampal seizure\u2010related burden metrics and examines their association with long\u2010term memory consolidation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 20 consecutive patients undergoing stereo\u2010electroencephalography in Marseille (2016\u20132018) were prospectively included. Continuous stereo\u2010electroencephalogram recordings between 2 memory assessments (30\u2009minutes and 1 week postencoding) were analyzed. Hippocampal ictal involvement and durations were assessed using epileptogenicity markers and visual stereo\u2010electroencephalogram analysis. The postictal period was quantified using permutation entropy. Cumulative hippocampal seizure\u2010related burden metrics (ictal, postictal, and combined) were computed across hippocampus\u2010involving ictal events. Verbal and visual memory were assessed using standardized recall and recognition tasks. One\u2010week performance was defined as the percentage score obtained at the 1\u2010week assessment, whereas retention was defined as 1\u2010week performance expressed as a percentage of 30\u2010min performance. Associations were examined using univariate and multivariate analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher dominant\u2010hemisphere hippocampal burden was associated with poorer 1\u2010week verbal memory (performance and retention), independently of most covariates. Higher cumulative hippocampal seizure\u2010related burden was associated with lower total recall performance (free\u2009+\u2009cued) and total recall retention (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u221225.04 and \u221223.88;\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.57 and 0.53;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), and accounted for the greatest variance in both outcomes (adjusted\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.59 and 0.53;\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u221225.45 and \u221224.27;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), particularly when adjusting for epilepsy duration. No robust associations were observed between nondominant\u2010hemisphere hippocampal seizure\u2010related burden metrics and visual memory. Effects predominantly involved recall.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Cumulative ictal\u2013postictal hippocampal dysfunction is a major predictor of impaired long\u2010term verbal memory consolidation in focal epilepsy. ANN NEUROL 2026<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.78354","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:02:22Z","timestamp":1788444142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hippocampal Seizure\u2010Related Burden is Associated with Accelerated Long\u2010Term Forgetting in Focal Epilepsy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8978-8927","authenticated-orcid":false,"given":"Ionu\u021b\u2010Flavius","family":"Bratu","sequence":"first","affiliation":[{"name":"Department of Epileptology and Cerebral Rhythmology Timone Hospital  Marseille France"},{"name":"Systems Neuroscience Institute Aix\u2010Marseille University, French National Institute of Health and Medical Research (UMR 1106)  Marseille 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Medina","family":"Villalon","sequence":"additional","affiliation":[{"name":"Department of Epileptology and Cerebral Rhythmology Timone Hospital  Marseille France"},{"name":"Systems Neuroscience Institute Aix\u2010Marseille University, French National Institute of Health and Medical Research (UMR 1106)  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Tr\u00e9buchon","sequence":"additional","affiliation":[{"name":"Department of Epileptology and Cerebral Rhythmology Timone Hospital  Marseille France"},{"name":"Systems Neuroscience Institute Aix\u2010Marseille University, French National Institute of Health and Medical Research (UMR 1106)  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1678-0297","authenticated-orcid":false,"given":"Fabrice","family":"Bartolomei","sequence":"additional","affiliation":[{"name":"Department of Epileptology and Cerebral Rhythmology Timone 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