{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:05:19Z","timestamp":1789567519189,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative dementia after Alzheimer's disease (AD), with significant pathological overlap between the two conditions. However, the impact of Alzheimer's co\u2010pathology on basal forebrain (BF) atrophy and its relationship with neurodegeneration and cognitive decline in patients with DLB remains underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty patients with DLB and 14 healthy controls (HCs) were included from the Centre for Neurodegenerative Diseases, University of Bari. Participants underwent neuropsychological evaluations, 3T magnetic resonance imaging (MRI) scans, and Alzheimer's biomarkers assessment. Patients with DLB were grouped by AD co\u2010pathology using in vivo biomarkers. BF and hippocampal volumes and mean cortical thickness values were analyzed using analysis of covariance (ANCOVA), adjusted for age, sex, and total intracranial volume. Mediation analyses were conducted to examine the indirect effects of Alzheimer's pathology and BF atrophy on neurodegeneration (hippocampal volume and cortical thickness) and cognitive function (Mini\u2010Mental State Examination [MMSE]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with DLB exhibited significant BF atrophy compared with HCs (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). AD co\u2010pathology was associated with greater BF atrophy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.046) and reduced mean cortical thickness (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025). Significant correlations were found between BF volume and the pTAU\n                      <jats:sub>181<\/jats:sub>\n                      \/A\u03b2\n                      <jats:sub>1\u221242<\/jats:sub>\n                      ratio (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009) and between BF volume and MMSE scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016). Mediation analysis revealed that BF atrophy mediated the relationship between the pTau\/A\u03b242 ratio and neurodegeneration, and that the BF has a direct association with cognitive impairment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>AD co\u2010pathology in DLB exacerbates BF atrophy, correlating with cognitive decline. These results emphasize the need to consider AD co\u2010pathology in evaluating neurodegeneration in DLB, suggesting future studies should explore targeted interventions to address this pathological overlap. ANN NEUROL 2026<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.78357","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:17:59Z","timestamp":1789564679000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alzheimer's Co\u2010Pathology Burden on Basal Forebrain Atrophy and Cognitive Impairment in Dementia with Lewy Bodies: A Cross\u2010Sectional Pilot Study"],"prefix":"10.1002","author":[{"given":"Daniele","family":"Urso","sequence":"first","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology University of Bari \u201cAldo Moro,\u201d Pia Fondazione Cardinale G. Panico  Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4323-9142","authenticated-orcid":false,"given":"Thomas","family":"Giannelli","sequence":"additional","affiliation":[{"name":"Department of Translational Biomedicine and Neuroscience (DiBraiN) University of Bari \u201cAldo Moro\u201d  Bari Italy"},{"name":"Department of Old Age Psychiatry, King's College London Institute of Psychiatry, Psychology, and Neuroscience  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Tafuri","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology University of Bari \u201cAldo Moro,\u201d Pia Fondazione Cardinale G. Panico  Lecce Italy"},{"name":"Department of Engineering of Innovation University of Salento  Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Giannoni\u2010Luza","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology University of Bari \u201cAldo Moro,\u201d Pia Fondazione Cardinale G. Panico  Lecce Italy"},{"name":"Department of Translational Biomedicine and Neuroscience (DiBraiN) University of Bari \u201cAldo Moro\u201d  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Gnoni","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology University of Bari \u201cAldo Moro,\u201d Pia Fondazione Cardinale G. Panico  Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Giugno","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology University of Bari \u201cAldo Moro,\u201d Pia Fondazione Cardinale G. Panico  Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Vilella","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology University of Bari \u201cAldo Moro,\u201d Pia Fondazione Cardinale G. Panico  Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Zecca","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology University of Bari \u201cAldo Moro,\u201d Pia Fondazione Cardinale G. 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