{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:08:34Z","timestamp":1789992514242,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to apply edge\u2010centric functional connectivity and motif analyses to capture co\u2010fluctuation communication patterns and test whether altered dynamic network integration underlies clinical manifestations of cluster headache (CH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study included 100 participants with episodic CH imaged during the in\u2010bout period outside acute attacks and 116 healthy controls (HCs) using functional magnetic resonance imaging (MRI). Robustness of the findings was assessed via pooled and separate analyses of 3 independent datasets using brain parcellation, edge graph construction, k\u2010means clustering, community entropy calculations, motif, and clinical correlation analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants with CH showed lower entropy in the cerebellar vermis (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.493, 95% confidence interval [CI]\u2009=\u2009\u22120.683 to \u22120.302,\n                      <jats:italic>p<\/jats:italic>\n                      false discovery rate [\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>FDR<\/jats:sub>\n                      ]\u2009=\u20093.02\u2009\u00d7\u200910\n                      <jats:sup>\u22126<\/jats:sup>\n                      ) and cerebellar network (mean difference\u2009=\u2009\u22120.043, 95% CI\u2009=\u2009\u22120.068 to \u22120.018,\n                      <jats:italic>t<\/jats:italic>\n                      \u2009=\u2009\u22123.361,\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>FDR<\/jats:sub>\n                      \u2009=\u20090.009) compared with HCs. In individuals with CH, longer disease duration was accompanied by a greater reduction in entropy of the cerebellar vermis (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.390, 95% CI\u2009=\u2009\u22120.550 to \u22120.196,\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>FDR<\/jats:sub>\n                      \u2009=\u20090.004). Motif analysis revealed that participants with CH exhibited (i) higher fractions of forked triads with vermis coordinating subcortical and cortical nodes belonging to sensorimotor, visual, default\u2010mode, and cerebellar networks; and (ii) lower fractions of diverse triads linking vermis to both sensorimotor and cognitive\u2010 control networks and to both sensorimotor and default\u2010mode networks (all\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>FDR<\/jats:sub>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>We identified reorganization of the cerebellar\u2013subcortical\u2013cortical network in CH. The cerebellar vermis exhibited a paradoxical pattern: retaining hub\u2010like connectivity while losing flexible network integration. This pattern worsened with disease duration, supporting its role in symptomatology and potential as a candidate region for future neuromodulation studies. ANN NEUROL 2026<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.78361","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:17:18Z","timestamp":1789989438000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dysregulated Cerebellar\u2013Subcortical\u2013Cortical Interactions in Cluster Headache: Evidence From Edge Analysis Across Three Independent Datasets"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7015-2531","authenticated-orcid":false,"given":"Wei","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Neurology First Medical Center of Chinese PLA General Hospital  Beijing People's Republic of China"},{"name":"Department of Neurology Fourth Medical Center of Chinese PLA General Hospital  Beijing People's Republic of 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