{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:01:56Z","timestamp":1790600516151,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Uncertainty persists over the effect of intensive blood pressure (BP) lowering on perihematomal edema (PHE) growth in acute spontaneous intracerebral hemorrhage (ICH). We aimed to investigate the effect of intensive BP lowering on PHE growth in acute ICH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We undertook an individual patient data pooled analysis of the 4 INTERACT trials, which all had consistent BP\u2010lowering protocols (targeting systolic BP &lt;140\u2009mmHg [intensive] vs &lt;180\u2009mmHg [guideline] within 1\u2009hour). PHE growth was defined as absolute volume increase and growth rate (volume increase divided by time interval [ml\/h]) at 24\u2009hours and 7\u2009days. Linear regression models were used to evaluate the treatment effect, adjusting for covariates including baseline hematoma volume. Heterogeneity analysis was undertaken to assess the interaction with time from symptom onset to randomization and other characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 2,549 ICH patients (mean age 64\u2009years, 35% female) with available 24\u2010hour PHE growth data were included. Early intensive BP lowering attenuated the absolute growth at 24\u2009hours (mean difference \u22121.13\u2009mL, 95% CI \u22121.94 to \u22120.33,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006), but did not influence growth rate or the 7\u2010day measures after adjustment. Furthermore, the treatment effect on the 24\u2010hour PHE growth decreased with increasing time from symptom onset to randomization, with the greatest benefit observed when treatment was initiated within 2.2\u2009h (\n                      <jats:italic>p<\/jats:italic>\n                      for interaction\u2009=\u20090.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Early intensive BP lowering significantly attenuates PHE growth at 24\u2009hours in acute ICH, with greater benefit when initiated earlier\u2014emphasizing the importance of early initiation of intensive BP lowering. ANN NEUROL 2026<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.78377","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:48:35Z","timestamp":1790599715000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Intensive Blood Pressure Lowering on Perihematomal Edema in Acute Intracerebral Hemorrhage: Pooled Analysis of the Four\n                    <scp>INTERACT<\/scp>\n                    Trials"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5235-894X","authenticated-orcid":false,"given":"Xinwen","family":"Ren","sequence":"first","affiliation":[{"name":"The George Institute for Global Health, Faculty of Medicine University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[{"name":"The George Institute for 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Medicine Clinical Alemana University of Desarrollo  Santiago Chile"},{"name":"Center for Clinical Studies, Institute of Sciences and Innovation in Medicine, Faculty of Medicine Cl\u00ednical Alemana University of Desarrollo  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Martins","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital Moinhos de Vento  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavio M.","family":"Pontes\u2010Neto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Song","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, Faculty of Medicine University of New South Wales  Sydney New South Wales Australia"},{"name":"Institute for 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