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Outer membrane vesicles (OMVs) shed from Gram\u2010negative bacteria are enriched with virulence factors and membrane lipids but heterogeneous in size and cargo. Herein, a vaccine platform combining precise and replicable nanoparticle technology with immunogenic <jats:italic>A. baumannii<\/jats:italic> OMVs (Ab\u2010OMVs) is reported. Gold nanoparticle cores coated with Ab\u2010OMVs (Ab\u2010NPs) induce robust IgG titers in rabbits that enhance human neutrophil opsonophagocytic killing and passively protect against lethal <jats:italic>A. baumannii<\/jats:italic> sepsis in mice. Active Ab\u2010NP immunization in mice protects against sepsis and pneumonia, accompanied by B cell recruitment to draining lymph nodes, activation of dendritic cell markers, improved splenic neutrophil responses, and mitigation of proinflammatory cytokine storm. 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