{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:40:30Z","timestamp":1789508430519,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"35","license":[{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,8,24]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Accessing structurally well\u2010defined polymer polymorphs remains extremely challenging because obtaining polymer single crystals suitable for atomic\u2010level structural characterization is rare. Here we report an unusual sequence of single\u2010crystal transformations in which a peptide monomer designed for topochemical azide\u2013alkyne cycloaddition (TAAC) undergoes spontaneous single\u2010crystal\u2010to\u2010single\u2010crystal (SCSC) polymerization to form a 1,4\u2010triazolyl\u2010linked polymer, despite a crystal packing seemingly predisposed for the formation of a 1,5\u2010linked product. Structural and computational analyses reveal that large\u2010amplitude rotations of the azide and alkyne groups enable the unexpected regioselectivity. Prolonged heating subsequently triggers a rare SCSC polymorphic transition of the polymer crystal, generating a second conformational polymorph with distinct chain packing and mechanical properties. These results demonstrate that sequential single\u2010crystal transformations can provide controlled access to polymer polymorphs from a single monomer crystal.<\/jats:p>","DOI":"10.1002\/anie.1002118","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T09:13:17Z","timestamp":1781946797000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sequential Single\u2010Crystal\u2010to\u2010Single\u2010Crystal Transformations Generate Polymer Polymorphs"],"prefix":"10.1002","volume":"65","author":[{"given":"Anu","family":"Lal","sequence":"first","affiliation":[{"name":"School of Chemistry Indian Institute of Science Education and Research Thiruvananthapuram  Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozhukunnon","family":"Mridula","sequence":"additional","affiliation":[{"name":"School of Chemistry Indian Institute of Science Education and Research Thiruvananthapuram  Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mithun C.","family":"Madhusudhanan","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Pittsburgh Chevron Science Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjana","family":"Siddharthan","sequence":"additional","affiliation":[{"name":"School of Chemistry Indian Institute of Science Education and Research Thiruvananthapuram  Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4005-3655","authenticated-orcid":false,"given":"Kana M.","family":"Sureshan","sequence":"additional","affiliation":[{"name":"School of Chemistry Indian Institute of Science Education and Research Thiruvananthapuram  Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780199655441.001.0001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CS00227C"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja403264c"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/9781420073225"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00283E"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.12.001"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400249d"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521\u20103773(19991203)38:23<3440::AID\u2010ANIE3440>3.0.CO;2\u2010"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2SC03909E"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c07767"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202500646"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201014733\u2010y"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC00053B"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119046233.ch5"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00638F"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201036871\u20109"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c08137"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c12454"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar8001427"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c00132"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201307672"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c05559"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c06371"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b12455"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja4102634"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja512697g"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c03643"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00398"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c10779"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202315742"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1718965115"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201055181\u20102"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c00978"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202502107"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c05415"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c06303"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202404084"},{"key":"e_1_2_8_39_1","first-page":"43","volume-title":"Advances 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