{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:06:33Z","timestamp":1790672793523,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22472126"],"award-info":[{"award-number":["22472126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22502151"],"award-info":[{"award-number":["22502151"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52306269"],"award-info":[{"award-number":["52306269"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22125304"],"award-info":[{"award-number":["22125304"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The efficient cleavage of C\u2500O bonds under mild conditions is essential for biomass upgrading yet remains challenging due to their kinetic inertness. Conventional MoS\n                    <jats:sub>2<\/jats:sub>\n                    catalysts require elevated temperatures or high sulfur\u2010vacancy densities to achieve meaningful activity. Here, we demonstrate that single\u2010atom tungsten substitution in MoS\n                    <jats:sub>2<\/jats:sub>\n                    (W\u2010MoS\n                    <jats:sub>2<\/jats:sub>\n                    ) dramatically enhances the intrinsic activity of edge sulfur vacancy sites for room\u2010temperature hydrodeoxygenation of 5\u2010hydroxymethylfurfural (HMF). The oxophilic W centers elongate C\u2500O bonds through strong oxygen coordination and lower the C\u2500O bond cleavage barrier, leading to a three\u2010fold increase in turnover frequency. The optimized W\u2010MoS\n                    <jats:sub>2<\/jats:sub>\n                    catalyst delivers complete HMF conversion with 100% selectivity toward a C6 fuel blend (a mixture of 2,5\u2010dimethylfuran and 1,2\u2010bis(5\u2010methyl\u20102\u2010furanyl)ethylene) under near\u2010ambient conditions. Notably, full HMF conversion is achieved even at room temperature, with a reaction rate constant three times that of pristine MoS\n                    <jats:sub>2<\/jats:sub>\n                    . This work establishes oxophilicity engineering as a powerful strategy to unlock the intrinsic potential of two\u2010dimensional sulfides for room\u2010temperature biomass refining.\n                  <\/jats:p>","DOI":"10.1002\/anie.1085066","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:38:18Z","timestamp":1790671098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oxophilicity\u2010Driven Room\u2010Temperature C\u2500O Cleavage Over Single\u2010Atom W\u2010Doped MoS\n                    <sub>2<\/sub>"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0714-5573","authenticated-orcid":false,"given":"Tangkang","family":"Liu","sequence":"first","affiliation":[{"name":"Interdisciplinary Institute of NMR and Molecular Sciences Academy of Advanced Interdisciplinary Research Wuhan University of Science and Technology  Wuhan P. R. China"},{"name":"Key Laboratory of Hubei Province for Coal Conversion and New Carbon Materials School of Chemistry and Chemical Engineering Wuhan University of Science and Technology  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3159-4465","authenticated-orcid":false,"given":"Jingpeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Interdisciplinary Institute of NMR and Molecular Sciences Academy of Advanced Interdisciplinary Research Wuhan University of Science and Technology  Wuhan P. R. China"},{"name":"Key Laboratory of Hubei Province for Coal Conversion and New Carbon Materials School of Chemistry and Chemical Engineering Wuhan University of Science and Technology  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Qian","sequence":"additional","affiliation":[{"name":"Interdisciplinary Institute of NMR and Molecular Sciences Academy of Advanced Interdisciplinary Research Wuhan University of Science and Technology  Wuhan P. R. China"},{"name":"Key Laboratory of Hubei Province for Coal Conversion and New Carbon Materials School of Chemistry and Chemical Engineering Wuhan University of Science and Technology  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1569-2957","authenticated-orcid":false,"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Interdisciplinary Institute of NMR and Molecular Sciences Academy of Advanced Interdisciplinary Research Wuhan University of Science and Technology  Wuhan P. R. China"},{"name":"Key Laboratory of Hubei Province for Coal Conversion and New Carbon Materials School of Chemistry and Chemical Engineering Wuhan University of Science and Technology  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6330-0460","authenticated-orcid":false,"given":"Yushan","family":"Wu","sequence":"additional","affiliation":[{"name":"Interdisciplinary Institute of NMR and Molecular Sciences Academy of Advanced Interdisciplinary Research Wuhan University of Science and Technology  Wuhan P. R. China"},{"name":"Key Laboratory of Hubei Province for Coal Conversion and New Carbon Materials School of Chemistry and Chemical Engineering Wuhan University of Science and Technology  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1575-254X","authenticated-orcid":false,"given":"Guoliang","family":"Liu","sequence":"additional","affiliation":[{"name":"Interdisciplinary Institute of NMR and Molecular Sciences Academy of Advanced Interdisciplinary Research Wuhan University of Science and Technology  Wuhan P. R. China"},{"name":"Key Laboratory of Hubei Province for Coal Conversion and New Carbon Materials School of Chemistry and Chemical Engineering Wuhan University of Science and Technology  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7115-6510","authenticated-orcid":false,"given":"Anmin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Interdisciplinary Institute of NMR and Molecular Sciences Academy of Advanced Interdisciplinary Research Wuhan University of Science and Technology  Wuhan P. R. China"},{"name":"Key Laboratory of Hubei Province for Coal Conversion and New Carbon Materials School of Chemistry and Chemical Engineering Wuhan University of Science and Technology  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1126337"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201031362\u20109"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202500881"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.4c00763"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2024.124592"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201020878\u20107"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.155867"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.checat.2022.04.009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fuel.2023.129433"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3872"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42004\u2010018\u20100033\u2010z"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2021.100189"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.3c02442"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2740"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929\u2010021\u201000584\u20103"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c00781"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4465"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202422953"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929\u2010023\u201001030\u20102"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.1c01201"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.1c03669"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ces.2024.119896"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.4384058"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4CS00472H"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms16104"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.6b02022"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.7b03010"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.133842"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201800396"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202409855"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201042325\u2010z"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcat.2008.03.007"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360\u20100564(08)60658\u20106"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44160\u2010023\u201000396\u20102"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.152729"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/la2000766"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.5b01678"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.0c05235"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929\u2010020\u20100445\u2010x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.3c02503"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.5b01930"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.1085066","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.1085066","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.1085066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:38:19Z","timestamp":1790671099000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.1085066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":41,"alternative-id":["10.1002\/anie.1085066"],"URL":"https:\/\/doi.org\/10.1002\/anie.1085066","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"assertion":[{"value":"2026-06-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1085066"}}