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Inspired by Derjaguin\u2013Landau\u2013Verwey\u2013Overbeek (DLVO) theory, in which multivalent ions promote colloid coagulation by compressing the electrical double layer and reducing electrostatic repulsion (Schulze\u2013Hardy rule: CCC \u221d 1\/z\n                    <jats:sup>6<\/jats:sup>\n                    ), we developed a strategy based on long\u2010range electrostatic interactions to construct high\u2011valent\u2011ion\u2010programmable J\u2010aggregates. By meso\u2011substituting positive or negative charged moieties to an anionic pentamethine cyanine (ACy5) to manipulate its stacking preference in ionic environment, we obtained probes capable of undergoing sharp J\u2011aggregation in response to high\u2011valent counterions (z \u2265 2). Benefiting from the long\u2011range nature of electrostatic interactions, ACy5\u2010Py\u20103Py exhibited anti\u2010concentration\u2011dependent assembly and formed stable J\u2011aggregates even at concentrations as low as 0.25\u00a0\u00b5M. Taking advantage of the multivalent\u2010anion\u2010rich bacterial membrane, we used ACy5\u2010Py\u20103Py to achieve in situ J\u2010aggregation on bacterial surfaces. The resulting aggregates exhibit potent phototherapeutic activity, enabling efficient bacterial theranostics and outperforming vancomycin in healing MRSA\u2010infected wounds in diabetic mice. No adverse effects were observed in sterile wounds, confirming high biocompatibility. Together with its specific bactericidal efficacy, ACy5\u2011Py\u20113Py represents a promising on\u2011demand phototheranostic J\u2011aggregate agent.\n                  <\/jats:p>","DOI":"10.1002\/anie.1142645","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:50:10Z","timestamp":1788511810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ion\u2011Programmed In Situ J\u2011Aggregates Overcome Concentration\u2010Dependence for On\u2010Demand Phototherapy of Diabetic Bacterial Infections"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0486-744X","authenticated-orcid":false,"given":"Haifeng","family":"Ge","sequence":"first","affiliation":[{"name":"Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education) College of Chemistry and Chemical Engineering Hunan Normal University  Changsha P. R. 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