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This operationally simple transformation allows for the introduction of not only well\u2010established CF\n                    <jats:sub>3<\/jats:sub>\n                    and CF\n                    <jats:sub>2<\/jats:sub>\n                    H groups, but also the synthetically (and medicinally) underexplored CF\n                    <jats:sub>2<\/jats:sub>\n                    Cl and CFClH motifs\u2014thereby broadening access to previously inaccessible chemical space of halogenated amine scaffolds. The method displays broad substrate scope and functional\u2010group tolerance while operating under mild conditions. Late\u2010stage functionalization of drug\u2010like derivatives of Oxaprozin, Erlotinib, and Ibuprofen (among others) is reported.\n                  <\/jats:p>","DOI":"10.1002\/anie.1233707","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:23:05Z","timestamp":1783678985000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unified Synthesis of Unconventional \u03b1\u2010Polyhalogenated Amines Through Hydroaminoalkylation"],"prefix":"10.1002","volume":"65","author":[{"given":"Angela K.","family":"Hofmeister","sequence":"first","affiliation":[{"name":"Institute of Organic Chemistry University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Iannelli","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Angyal","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustin","family":"Malandain","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8895-9969","authenticated-orcid":false,"given":"Daniel","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Maryasin","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanspeter","family":"K\u00e4hlig","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2894-8608","authenticated-orcid":false,"given":"Matteo","family":"Barel","sequence":"additional","affiliation":[{"name":"Institute of Science and Technology Austria  Klosterneuburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Novarino","sequence":"additional","affiliation":[{"name":"Institute of Science and Technology Austria  Klosterneuburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3643-0718","authenticated-orcid":false,"given":"Nuno","family":"Maulide","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm3012068"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53748-5.00001-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00258"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200300833"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.0c00830"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.200700059"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470281895"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","unstructured":"P.ShahandA. D.Westwell \u201cThe role of fluorine in medicinal chemistry \u201dJournal of Enzyme Inhibition and Medicinal Chemistry22(2007):527\u2013540. For a direct example: M. B. Van Niel I. Collins M. S. Beer H. B. Broughton S. K. F. Cheng S. C. Goodacre A. Heald K. L. Locker A. M. MacLeod D. Morrison C. R. Moyes D. O'Connor A. Pike M. Rowley M. G. N. Russell B. Sohal J. A. Stanton S. Thomas H. Verrier A. P. Watt J. L. 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