{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:50:32Z","timestamp":1791229832836,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"41","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2022YFA1205200"],"award-info":[{"award-number":["2022YFA1205200"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,10,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    While electrocatalytic C\u2500N coupling offers a promising route for amino acid synthesis, its efficiency is limited by complex reaction pathways and competitive adsorption of reactants and intermediates on single\u2010site catalysts. Herein, we report a catalyst with F and Zn diatomic sites on MnO\n                    <jats:sub>2\u2010x<\/jats:sub>\n                    that enables the efficient synthesis of various amino acids from keto acids and nitrate through electrocatalytic C\u2500N coupling in neutral electrolytes. For alanine synthesis, this catalyst exhibits a high Faradaic efficiency (FE) of 76.25% and a production rate of 543.02\u00a0\u00b5mol cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    h\n                    <jats:sup>\u22121<\/jats:sup>\n                    across a broad potential window from \u20130.3 to \u20131.3 V\n                    <jats:sub>RHE<\/jats:sub>\n                    , while maintaining stable operation for over 300\u00a0h. In a membrane electrode assembly reactor, the catalyst sustains stable alanine production for 200\u00a0h with an average FE of 70.86%, enabling the practical isolation of 44.72\u00a0g of alanine. In situ spectroscopic and theoretical calculations demonstrate a tandem catalytic cascade, in which nitrate reduction proceeds to NH\n                    <jats:sub>2<\/jats:sub>\n                    OH on MnO\n                    <jats:sub>2\u2010x<\/jats:sub>\n                    , NH\n                    <jats:sub>2<\/jats:sub>\n                    OH then spontaneously condenses with keto acids adsorbed on Zn sites to form C\u2550N oxime intermediates, and these oximes migrate to F sites for hydrogenation to amino acids. This work offers insights into diatomic\u2010site design for amino acid electrosynthesis and promotes the sustainable production of high\u2010value organonitrogen compounds.\n                  <\/jats:p>","DOI":"10.1002\/anie.1293701","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T14:23:53Z","timestamp":1787149433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Zn\u2500F Diatomic Sites Promote Electrochemical C\u2500N Coupling for the Synthesis of Amino Acids"],"prefix":"10.1002","volume":"65","author":[{"given":"Jidong","family":"Yu","sequence":"first","affiliation":[{"name":"College of Chemistry and Chemical Engineering College of Energy Material and Chemistry Inner Mongolia University  Hohhot China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7140-7305","authenticated-orcid":false,"given":"Rui\u2010Ting","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering College of Energy Material and Chemistry Inner Mongolia University  Hohhot China"},{"name":"College of Smart Materials and Future Energy Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering College of Energy Material and Chemistry Inner Mongolia University  Hohhot China"},{"name":"College of Smart Materials and Future Energy Fudan University  Shanghai 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