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Here, we report a programmable communication framework that integrates logic\u2010gated DNA signal processing with cascade amplification to enable high\u2010fidelity chemical messaging between synthetic sender and receiver protocells. Sender protocells are equipped with membrane\u2010anchored DNA logic circuits that release a messenger strand only upon dual\u2010input recognition, while receiver protocells decode the transmitted signal through a surface\u2010confined hybridization chain reaction that amplifies the response and suppresses false\u2010positive activation. Beyond information transfer, the amplified signal is converted into functional execution by recruiting a photosensitizer to the receiver membrane, enabling light\u2010triggered modulation of membrane integrity and controlled molecular transport. Together, this logic\u2010controlled and cascade\u2010amplified communication system establishes a signal\u2010to\u2010function transduction pathway in synthetic protocell communities, providing a versatile strategy for constructing synthetic multicellular networks with enhanced communication fidelity, long\u2010range signaling capability, and programmable downstream responses.<\/jats:p>","DOI":"10.1002\/anie.1298760","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:24:17Z","timestamp":1790065457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Logic\u2010Gated DNA Cascade Amplification Enables High\u2010Fidelity Intercellular Communication in Synthetic Protocells"],"prefix":"10.1002","author":[{"given":"Shuangna","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemo and Biosensing College of Biology College of Chemistry and Chemical Engineering Key Laboratory for Bio\u2010Nanotechnology and Molecular Engineering of Hunan Province Hunan University  Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemo and Biosensing College of Biology College of Chemistry and Chemical Engineering Key Laboratory for Bio\u2010Nanotechnology and Molecular Engineering of Hunan Province Hunan University  Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9390-4938","authenticated-orcid":false,"given":"Kemin","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemo and Biosensing College of Biology College of Chemistry and Chemical Engineering Key Laboratory for Bio\u2010Nanotechnology and Molecular Engineering of Hunan Province Hunan University  Changsha P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8282-4078","authenticated-orcid":false,"given":"Jianbo","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemo and Biosensing College of Biology College of Chemistry and Chemical Engineering Key Laboratory for Bio\u2010Nanotechnology and Molecular Engineering of Hunan Province Hunan University  Changsha P. R. China"},{"name":"Key Laboratory of Chemical Biology &amp; Traditional Chinese Medicine Research (Ministry of Education) Key Laboratory of Phytochemical R&amp;D of Hunan Province College of Chemistry and Chemical Engineering Hunan Normal University  Changsha P. R. 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