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Radical\u2011trapping antioxidants (RTAs) effectively prevent lipid peroxidation (LPO) and constitute the largest and most important class of ferroptosis inhibitors. However, current approaches for compound discovery and mechanistic studies rely almost exclusively on phenolic or aromatic amine scaffolds, which are typically identified via labor\u2011intensive high\u2011throughput screening or adapted from classical antioxidants. Here, we demonstrate that Blatter radicals potently inhibit autoxidation and suppress ferroptosis. Beyond their intrinsic potent radical\u2011trapping capability, these compounds exhibit super\u2011stoichiometric activity in inhibiting (phospho)lipid peroxidation through an unusual catalytic cross\u2011dismutation of lipid peroxyl radicals (LOO\u2022) and hydroperoxyl radicals (HOO\u2022). Importantly, this potent chemical reactivity translates effectively into biological systems: Blatter radicals confer broad anti\u2011ferroptotic cytoprotection at low nanomolar concentrations, effectively protect against oxygen\u2011glucose deprivation\/reperfusion (OGD\/R) injury, and exert strong anti\u2011inflammatory effects in lipopolysaccharide (LPS)\u2011stimulated BV2 microglial cells. Collectively, our results highlight the unprecedented versatility of Blatter radicals\u2014extending from stable radicals to RTAs\u2014and validate a rational design strategy for potent ferroptosis inhibitors.<\/jats:p>","DOI":"10.1002\/anie.1404527","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:26:18Z","timestamp":1790004378000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Stable Radicals to Radical\u2011Trapping Antioxidants: Blatter Radicals Potently Inhibit Autoxidation and Suppress Ferroptosis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0449-9152","authenticated-orcid":false,"given":"Cuiling","family":"Ouyang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Anti\u2011Infective Drug Discovery and Development Provincial Key Laboratory of Chiral Molecule and Drug Discovery School of Pharmaceutical Sciences Sun Yat\u2011sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6199-5527","authenticated-orcid":false,"given":"Jiaying","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Anti\u2011Infective Drug Discovery and Development Provincial Key Laboratory of Chiral Molecule and Drug Discovery School of Pharmaceutical Sciences Sun Yat\u2011sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"He","sequence":"additional","affiliation":[{"name":"College of Life Sciences Hebei Agricultural University  Baoding China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengsen","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Life Sciences Hebei Agricultural University  Baoding China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5030-071X","authenticated-orcid":false,"given":"Zijun","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Anti\u2011Infective Drug Discovery and Development Provincial Key Laboratory of Chiral Molecule and Drug Discovery School of Pharmaceutical Sciences Sun Yat\u2011sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr200084z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13091291"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS00265A"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrp.2023.101683"},{"key":"e_1_2_9_6_1","first-page":"140","article-title":"Differential Contributions of Distinct Free 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