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Notably, the previously reported coupling reactions of C(sp\n                    <jats:sup>3<\/jats:sup>\n                    )\u2500H bonds with vinyl halides employing Pd\n                    <jats:sup>II<\/jats:sup>\n                    \/Pd\n                    <jats:sup>IV<\/jats:sup>\n                    catalysis are highly limited in two ways: activated alkenyl halides and strong external directing groups were typically required. Here, we report stereoselective C(sp\n                    <jats:sup>3<\/jats:sup>\n                    )\u2500C(sp\n                    <jats:sup>2<\/jats:sup>\n                    ) cross\u2010coupling of methylene C(sp\n                    <jats:sup>3<\/jats:sup>\n                    )\u2500H bonds from aliphatic acids with alkenyl bromides via Pd\n                    <jats:sup>II<\/jats:sup>\n                    \/Pd\n                    <jats:sup>0<\/jats:sup>\n                    \/Pd\n                    <jats:sup>II<\/jats:sup>\n                    catalysis. A diverse array of readily available cyclic and acyclic aliphatic acids and various alkenyl bromides were coupled smoothly, affording a versatile method for forging C(sp\n                    <jats:sup>3<\/jats:sup>\n                    )\u2500C(sp\n                    <jats:sup>2<\/jats:sup>\n                    ) bonds. Complex acids and the alkenyl bromide coupling partners derived from natural products and pharmaceuticals are compatible, rendering this method amenable to late\u2010stage modification. The stereoselectivity of this C(sp\n                    <jats:sup>3<\/jats:sup>\n                    )\u2500C(sp\n                    <jats:sup>2<\/jats:sup>\n                    ) coupling reaction with respect to both the sp\n                    <jats:sup>3<\/jats:sup>\n                    carbon center and the double bond configuration is a valuable feature.\n                  <\/jats:p>","DOI":"10.1002\/anie.1441281","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T13:52:36Z","timestamp":1782136356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ligand\u2010Enabled Stereoselective Coupling of Methylene C(sp\n                    <sup>3<\/sup>\n                    )\u2500H Bonds With Alkenyl Bromide via Pd\n                    <sup>II<\/sup>\n                    \/Pd\n                    <sup>0<\/sup>\n                    \/Pd\n                    <sup>II<\/sup>\n                    Catalysis"],"prefix":"10.1002","volume":"65","author":[{"given":"Zi\u2010Yu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Chemistry The Scripps Research Institute  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry The Scripps Research Institute  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Chemistry The Scripps Research Institute  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Chemistry The Scripps Research Institute  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3560-5774","authenticated-orcid":false,"given":"Jin\u2010Quan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Chemistry The Scripps Research Institute  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.0c00093"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.1c00251"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01409"},{"key":"e_1_2_6_5_1","first-page":"1","volume-title":"Synthetic Methods in Drug Discovery","author":"Blakemore D. 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