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In this study, we introduce a defect engineering strategy to synthesize sulfur vacancies (S\n                    <jats:sub>v<\/jats:sub>\n                    ) enriched Cu\n                    <jats:sub>4<\/jats:sub>\n                    SnS\n                    <jats:sub>4\u2212x<\/jats:sub>\n                    nanosheets with promising thermoelectric properties, followed by loading small\u2010molecule inhibitor NLG919. Spherical aberration corrected transmission electron microscopy and X\u2010ray absorption fine structure reveal the fine structural characteristics of S\n                    <jats:sub>v<\/jats:sub>\n                    , which make the nanosheets possess an ultra\u2010high photothermal conversion efficiency of 64.7% under 808\u00a0nm laser irradiation. This generates a localized temperature gradient that induces an internal electric field, which enhances carrier separation, boosts peroxidase\u2010 and catalase\u2010like activities, and produces substantial amounts of reactive oxygen species (ROS), enabling cooperative PTECT and multi\u2010enzymatic catalytic therapy. Density functional theory calculations show that S\n                    <jats:sub>v<\/jats:sub>\n                    reduces the thermal conductivity, thus enhancing the figure of merit value and the PTECT effect. Accumulation of Cu ions, ROS, and heat triggers cuproptosis, mitochondrial apoptosis, and endoplasmic reticulum\u2010based immunogenic cell death. The released NLG919 disrupts the IDO\u2010induced Trp\/Kyn metabolic pathway, reversing the tumor immune suppressive microenvironment. This integrated approach achieves high efficiency (96%) and long\u2010term anticancer efficacy. These findings may provide valuable insights for advancing thermoelectric materials in tumor therapy.\n                  <\/jats:p>","DOI":"10.1002\/anie.1499416","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:46:02Z","timestamp":1782823562000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sulfur Vacancy\u2010Enriched Cu\n                    <sub>4<\/sub>\n                    SnS\n                    <sub>4\u2212x<\/sub>\n                    Nanosheets Enable Synergistic Cuproptosis, Photothermoelectric Catalytic and Immunotherapy"],"prefix":"10.1002","volume":"65","author":[{"given":"Lu","family":"Yang","sequence":"first","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology College of Materials Science and Chemical Engineering Ministry of Education, Harbin Engineering University  Harbin P. R. China"},{"name":"Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The First Affiliated Hospital of Harbin Medical University  Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9653-4944","authenticated-orcid":false,"given":"Shili","family":"Gai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology College of Materials Science and Chemical Engineering Ministry of Education, Harbin Engineering University  Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Zang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology College of Materials Science and Chemical Engineering Ministry of Education, Harbin Engineering University  Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqi","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology College of Materials Science and Chemical Engineering Ministry of Education, Harbin Engineering University  Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghao","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology College of Materials Science and Chemical Engineering Ministry of Education, Harbin Engineering University  Harbin P. R. 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