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For syngas\u2010to\u2010methanol conversion over Cu\/Zn\/Al (CZA) catalysts, product retention and re\u2010adsorption represent an underappreciated limitation governing both activity and selectivity. Methanol generated at metal\u2013oxide interfaces tends to remain near active sites, where interactions with surface hydroxyls trigger secondary reactions such as the water\u2013gas shift. By physically mixing commercial CZA with hydrogen\u2010bond\u2010rich porous frameworks, we introduce a non\u2010covalent host\u2013guest extraction pathway that captures methanol from the interfacial region and facilitates its release into the gas phase. This extraction shifts the local adsorption\u2013desorption equilibrium, suppresses methanol re\u2010adsorption, and boosts methanol space\u2013time yield by 1.12\u20131.43 times relative to pristine CZA, while retaining &gt; 92.3% selectivity. In situ spectroscopy, transient kinetics, and simulations confirm the porous framework acts as a molecular sink, regulating methanol residence time and transport without direct catalytic participation. This effect is general across distinct metal\u2013organic and covalent organic frameworks, establishing non\u2010covalent extraction as a transferable strategy. This work demonstrates that non\u2010covalent control of product desorption and transport serves as a complementary design principle for heterogeneous catalysis beyond conventional active\u2010site engineering.<\/jats:p>","DOI":"10.1002\/anie.1543450","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:45:32Z","timestamp":1787226332000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Non\u2010Covalent Host\u2013Guest Extraction of Methanol Enables Enhanced Syngas\u2010to\u2010Methanol Conversion Over Hybrid Oxide\u2013Porous Framework Catalysis"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7057-0867","authenticated-orcid":false,"given":"Guo","family":"Tian","sequence":"first","affiliation":[{"name":"Ordos Laboratory  Ordos China"},{"name":"Research Institute of Frontier Science Southwest Jiaotong University  Chengdu 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Key Laboratory of Chemical Engineering and Low\u2010Carbon Technology, Department of Chemical Engineering Tsinghua University  Beijing China"},{"name":"Institute For Carbon Neutrality Tsinghua University  Beijing 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