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Herein, we developed a cascade strategy integrating vacancy induction and electrostatic adsorption to construct two representative Fe DA nanozymes, pr\u2010Fe\u2010DA and py\u2010Fe\u2010DA, with coordination environments dominated by pyrrolic\u2010N and pyridinic\u2010N, respectively. The resulting py\u2010Fe\u2010DA exhibits an exceptionally high CAT\u2010like activity of 100 U mg\n                    <jats:sup>\u22121<\/jats:sup>\n                    , which is 2.4 times that of pr\u2010Fe\u2010DA (42 U mg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), representing the highest value reported to date. Mechanistic studies and density functional theory calculations reveal that modulating the nitrogen coordination environment from pyrrolic\u2010N to pyridinic\u2010N promotes an antiferromagnetic\u2010to\u2010ferromagnetic transition in the magnetic coupling between Fe sites. This transition enables spin\u2010favorable H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    activation through parallel spin alignment of the oxygen atoms in adsorbed H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , thereby accelerating O\u2500H bond cleavage and O\n                    <jats:sub>2<\/jats:sub>\n                    generation while decreasing the Gibbs free energy change of the rate\u2010determining step from 0.84 to 0.08\u00a0eV. Moreover, py\u2010Fe\u2010DA effectively alleviates oxidative stress and inflammation in rheumatoid arthritis models. These findings identify magnetic coupling as a key descriptor of CAT\u2010like activity and establish magnetic\u2010coupling engineering as a powerful strategy for designing high\u2010performance nanozymes.\n                  <\/jats:p>","DOI":"10.1002\/anie.1653347","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:37:45Z","timestamp":1785940665000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ferromagnetic Coupling in Dual\u2010Atom Nanozymes Enables Spin\u2010Favorable Catalase\u2010Like Catalysis for Rheumatoid Arthritis Therapy"],"prefix":"10.1002","volume":"65","author":[{"given":"Xiangfu","family":"Meng","sequence":"first","affiliation":[{"name":"High Magnetic Field Laboratory Hefei Institutes of Physical Science Chinese Academy of Sciences  Hefei Anhui P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences  Beijing P. R. China"},{"name":"Chinese Academy of Sciences University of Chinese Academy of Sciences  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6285-1933","authenticated-orcid":false,"given":"Kelong","family":"Fan","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences University of Chinese Academy of Sciences  Beijing P. R. China"},{"name":"Nanozyme Laboratory in Zhongyuan Henan Academy of Innovations in Medical Science  Zhengzhou Henan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0142-8522","authenticated-orcid":false,"given":"Xiangyang","family":"Li","sequence":"additional","affiliation":[{"name":"Hefei National Laboratory University of Science and Technology of China  Hefei Anhui P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9732-4367","authenticated-orcid":false,"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory Hefei Institutes of Physical Science Chinese Academy of Sciences  Hefei Anhui P. R. China"},{"name":"Hefei National Laboratory University of Science and Technology of China  Hefei Anhui P. R. 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