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However, the diastereoselective synthesis of these scaffolds remains a formidable challenge. Herein, we report a novel photocatalytic cascade enabling the one\u2010pot hydrogenation, carboxylation, and epimerization of\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ,\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010unsaturated imines. This method provides direct and highly diastereoselective (d.r. up to 35:1) access to valuable\n                    <jats:italic>syn<\/jats:italic>\n                    \u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    <jats:sup>2,3<\/jats:sup>\n                    \u2010amino acids. Time\u2010course analysis and DFT calculations reveal a unique light\u2010driven dynamic kinetic epimerization process that ensures stereoconvergence to the thermodynamically favored\n                    <jats:italic>syn<\/jats:italic>\n                    \u2010isomer. Notably, this strategy also facilitates the facile synthesis of\n                    <jats:sup>13<\/jats:sup>\n                    C\u2010labeled\n                    <jats:italic>syn<\/jats:italic>\n                    \u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    <jats:sup>2,3<\/jats:sup>\n                    \u2010amino acids using commercially available\n                    <jats:sup>13<\/jats:sup>\n                    C\u2010sodium formate, achieving exceptional isotope incorporation (93%\u201398%) that surpasses existing\n                    <jats:sup>13<\/jats:sup>\n                    CO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010based methods. Furthermore, the system's utility is demonstrated through the gram\u2010scale synthesis of N\u2010unprotected\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010amino acids from imines (11\u00a0g, 75% yield), more significantly, via a one\u2010pot procedure directly from diaryl ketones.\n                  <\/jats:p>","DOI":"10.1002\/anie.1668497","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T18:52:38Z","timestamp":1781290358000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Light\u2010Driven Epimerization: Diastereoconvergent Synthesis of [\n                    <sup>12<\/sup>\n                    C,\n                    <sup>13<\/sup>\n                    C]\n                    <i>\u03b2<\/i>\n                    <sup>2,3<\/sup>\n                    \u2010Amino 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