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Although stoichiometric EDA photochemistry is now well established, its translation into catalysis is a more recent advance that requires charge\u2010transfer excitation to be integrated with catalyst regeneration and productive turnover. This review focuses on the design principles that enable EDA complex catalysis, combining fundamental physical\u2013organic concepts with mechanistic criteria for identifying productive catalytic manifolds. Current catalytic approaches are organized into donor\u2010based, acceptor\u2010based, and hybrid platforms, with emphasis on how transient catalytic species, medium effects, supramolecular organization, and confined environments facilitate EDA complex formation and expand the range of accessible synthetic transformations. By defining how photoactive donor\u2013acceptor assemblies can be generated, activated, and regenerated within catalytic cycles, this review provides a framework for designing selective and synthetically useful light\u2010driven catalytic radical processes.<\/jats:p>","DOI":"10.1002\/anie.1736780","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:09:31Z","timestamp":1791518971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electron Donor\u2013Acceptor Complex Catalysis in Synthetic Chemistry"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8911-6733","authenticated-orcid":false,"given":"Tristan","family":"von M\u00fcnchow","sequence":"first","affiliation":[{"name":"Department of Industrial Chemistry \u201cToso Montanari\u201d University of Bologna Bologna 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