{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:04:56Z","timestamp":1791227096949,"version":"4.1.0"},"reference-count":77,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 115\u20102628\u2010M\u2010110\u2010002"],"award-info":[{"award-number":["NSTC 115\u20102628\u2010M\u2010110\u2010002"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 115\u20102113\u2010M\u2010110\u2010014\u2010MY4"],"award-info":[{"award-number":["NSTC 115\u20102113\u2010M\u2010110\u2010014\u2010MY4"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Given the prominence of azetidine derivatives in pharmaceutical chemistry, developing their catalytic synthesis continues to attract strong attention from synthetic chemists. While the strain\u2010release ring opening and functionalizations of 1\u2010azabicyclo[1.1.0]butanes (ABBs) has become a promising route to access diverse azetidines and 1\u2010azabicyclic molecules since their discovery in the late 1960s, such transformations were mostly operated under stoichiometric conditions, and reactions facilitated by catalysis have only emerged recently. The integration of catalysis in ABB chemistry has enabled innovative reaction development, particularly through the interception of transient reaction intermediates\u2014for instance,\n                    <jats:italic>C3\u2010<\/jats:italic>\n                    radical and\n                    <jats:italic>N1\u2010<\/jats:italic>\n                    anion\n                    <jats:italic>\u2014<\/jats:italic>\n                    to allow divergent transformations, thereby achieving unprecedented synthetic versatility. This mini\u2010review summarizes recent advances in catalytic strain\u2010release ring opening and functionalizations of ABBs from a mechanistic\u2010centered perspective. The reaction pathways are categorized into polar ring opening, radical ring opening, and polar ring opening with radical crossover. The features of each class of reaction are presented for the identification of mechanistic commonalities and differences across diverse transformations.\n                  <\/jats:p>","DOI":"10.1002\/anie.1799115","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:27:23Z","timestamp":1788949643000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["1\u2010Azabicyclo[1.1.0]butanes (ABBs) on the Map: Mechanistic Pathways for Catalytic Ring Opening and Functionalizations"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2068-3692","authenticated-orcid":false,"given":"James Shao\u2010Jiun","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Chemistry National Sun Yat\u2010Sen University  Kaohsiung Taiwan"},{"name":"Department of Chemistry Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7825-2425","authenticated-orcid":false,"given":"Hsuan\u2010Hung","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Chemistry National Sun Yat\u2010Sen University  Kaohsiung Taiwan"},{"name":"Department of Chemistry Kaohsiung Medical University  Kaohsiung 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