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Aliphatic primary amines are widespread functional groups, yet their direct use as alkylating reagents is limited by the strength of the C(sp\n                    <jats:sup>3<\/jats:sup>\n                    )\u2500N bond. Herein, we describe a direct deaminative alkynylation of aliphatic primary amines using alkynyl bromides as coupling partners. The transformation proceeds under metal\u2010free conditions with an\n                    <jats:italic>N<\/jats:italic>\n                    \u2010anomeric amide as a nitrogen\u2010deletion reagent, enabling formation of C(sp\n                    <jats:sup>3<\/jats:sup>\n                    )\u2500C(sp) bonds without prior amine prefunctionalization. The reaction shows good functional\u2010group tolerance and accommodates a range of aliphatic amines, including substrates derived from pharmaceuticals and natural products. This study demonstrates the feasibility of converting aliphatic primary amines into internal alkynes and expands the scope of deaminative C\u2500C bond\u2010forming reactions.\n                  <\/jats:p>","DOI":"10.1002\/anie.1809869","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T07:36:40Z","timestamp":1782805000000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Direct Deaminative Alkynylation of Aliphatic Primary Amines"],"prefix":"10.1002","volume":"65","author":[{"given":"Jia\u2010Luo","family":"Fu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Anti\u2010Infective Drug Discovery and Development Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery School of Pharmaceutical Sciences Sun Yat\u2010sen University  Guangzhou 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