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The pivotal role of the Lewis acid in enabling the activation of the strong and low\u2010polarity Si\u2500Me bond was elucidated via stoichiometric experiments. According to DFT calculations, the Lewis acid acts as a Me\n                    <jats:sup>\u2212<\/jats:sup>\n                    acceptor and triggers the formation of the key cationic silyl Pd complex responsible for the alkyl exchange at Si. This unprecedented Si\u2500Me bond transformation has been demonstrated in a four\u2010step sequence, enabling the stepwise upgrading of Me\n                    <jats:sub>3<\/jats:sub>\n                    SiCl into silanols bearing diverse organic substituents.\n                  <\/jats:p>","DOI":"10.1002\/anie.1850136","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:00:00Z","timestamp":1787580000000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["P\u2010Directed and Lewis Acid\u2010Assisted Pd\u2010Catalyzed Si\u2500Me Bond Activation Enabling Alkyl Exchange at Silicon"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6901-6372","authenticated-orcid":false,"given":"Hajime","family":"Kameo","sequence":"first","affiliation":[{"name":"Department of Chemistry Graduate School of Science Osaka Metropolitan University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanta","family":"Oishi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Graduate School of Science Osaka Metropolitan University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keitaro","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Chemistry Graduate School of Science Osaka Metropolitan University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Mushiake","sequence":"additional","affiliation":[{"name":"Department of Chemistry Graduate School of Science Osaka Metropolitan University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Matsuzaka","sequence":"additional","affiliation":[{"name":"Department of Chemistry Graduate School of Science Osaka Metropolitan University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0249-1769","authenticated-orcid":false,"given":"Didier","family":"Bourissou","sequence":"additional","affiliation":[{"name":"Laboratoire H\u00e9t\u00e9rochimie Fondamentale et Appliqu\u00e9e Universit\u00e9 de Toulouse\/CNRS UMR 5069 Toulouse Cedex 09 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"https:\/\/www.grandviewresearch.com\/industry\u2010analysis\/silane\u2010market."},{"key":"e_1_2_6_3_1","first-page":"89","article-title":"Direct Synthesis of Silicon Compounds\u2014From the Beginning to Green Chemistry Revolution","volume":"3","author":"Paku\u0142a D.","year":"2023","journal-title":"Applied Chemistry"},{"key":"e_1_2_6_4_1","unstructured":"\u201cBasic Silicone Chemistry\u2014A Review\u201dhttps:\/\/www.scientificspectator.com\/documents\/silicone%20spectator\/Silicone_Spectator_January_2009.pdf."},{"key":"e_1_2_6_5_1","volume-title":"Silicon in Organic, Organometallic, and Polymer Chemistry","author":"Brook M. 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However these complexes proved too labile for definitive identification."},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/om900874p"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200904570"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3dt32896a"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja410822p"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2012.07.072"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201403220"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/om501238d"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.9b01388"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0DT00725K"},{"key":"e_1_2_6_42_1","unstructured":"In solution complex6exists as a mixture of two diastereoisomers (\u223c 1:1) one featuring the Et group oriented inward and the other featuring the Me group oriented inward. Variable\u2010temperature NMR studies established dynamic interconversion involving the silicon\u2010bound Me and Et substituents (see ref.37)."},{"key":"e_1_2_6_43_1","unstructured":"Deposition Numbers 2524903 (7BArF4$\\mathbf{7}^{\\mathbf{BArF_4}}$) and 2524904 (9) contain the supplementary crystallographic data for this paper. These data are provided free of charge by the joint Cambridge Crystallographic Data Centre and Fachinformationszentrum Karlsruhe Access Structures service."},{"key":"e_1_2_6_44_1","unstructured":"Gaussian09 (Revision D.01)M. J.Frisch G. W.Trucks andH. 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