{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T14:13:18Z","timestamp":1789740798648,"version":"4.0.1"},"reference-count":103,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["SRG\/2021\/001423"],"award-info":[{"award-number":["SRG\/2021\/001423"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000964","name":"Arthritis National Research Foundation","doi-asserted-by":"publisher","award":["ANRF\/IRG\/2024\/001541\/PS"],"award-info":[{"award-number":["ANRF\/IRG\/2024\/001541\/PS"]}],"id":[{"id":"10.13039\/100000964","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The concept of homochirality is fundamental to living systems, where biopolymers exhibit a uniform chiral signature. The absence of heterochiral or racemic biopolymers in nature highlights the importance of homochirality in precise molecular recognition, efficient packing, and controlled folding for maintaining cellular homeostasis and biological function. However, the role of homochirality in governing emergent functional properties in synthetic supramolecular nanomaterials has been less explored. Here, we investigate homochiral recognition of dipeptides at their co\u2010assembled state. Homochiral peptides on co\u2010assembly form supramolecular gels, whereas heterochiral peptides fail to gelify. Co\u2010assembly of homochiral peptides results in the formation of long\u2010range fibrillar network with high aspect ratios, while co\u2010assembly of heterochiral peptides produces short\u2010range, discrete morphology. Computational insight further reveals that dipeptides containing similar chiral \u03b1\u2010amino acids promote efficient molecular packing and long\u2010range \u03c0\u2013\u03c0 stacking, whereas dipeptides with opposite chirality disrupt these interactions, leading to short\u2010range assembly. The preference for like\u2010like interactions in homochiral co\u2010assemblies has been explored through FRET and piezoelectric measurements. Homochiral assembly exhibits significantly higher energy\u2010transfer efficiency and enhanced piezoelectric properties than heterochiral assembly. Overall, this study highlights the fundamental concept of homochirality in nature and its relationship with emergent functional properties.<\/jats:p>","DOI":"10.1002\/anie.1859339","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:56:42Z","timestamp":1789739802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chirality\u2010Matched Piezoelectric Responsiveness and Energy Transfer in Supramolecular Co\u2010Assembly of Dipeptides"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2172-9719","authenticated-orcid":false,"given":"Soumen","family":"Kuila","sequence":"first","affiliation":[{"name":"Department of Chemistry University of North Bengal Raja Rammohanpur Siliguri  Darjeeling West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6591-2628","authenticated-orcid":false,"given":"Riya","family":"Nag","sequence":"additional","affiliation":[{"name":"Department of Physics Midnapore College (Autonomous)  Midnapore West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1373-1543","authenticated-orcid":false,"given":"Krishnandu","family":"Dey","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Science NIT\u2010Meghalaya  Sohra Meghalaya India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8178-5662","authenticated-orcid":false,"given":"Anirban","family":"Samanta","sequence":"additional","affiliation":[{"name":"Department of Physics Midnapore College (Autonomous)  Midnapore West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4950-6777","authenticated-orcid":false,"given":"Kolimi Prashanth","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics National Institute of Pharmaceutical Education and Research Kolkata (NIPER\u2010K)  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laboni","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of North Bengal Raja Rammohanpur Siliguri  Darjeeling West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5929-3907","authenticated-orcid":false,"given":"Ajay Haridas","family":"CP","sequence":"additional","affiliation":[{"name":"Rubber Technology Centre Indian Institute of Technology Kharagpur  Kharagpur West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayantani","family":"Khatua","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of North Bengal Raja Rammohanpur Siliguri  Darjeeling West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0825-6337","authenticated-orcid":false,"given":"Titash","family":"Mondal","sequence":"additional","affiliation":[{"name":"Rubber Technology Centre Indian Institute of Technology Kharagpur  Kharagpur West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7404-4917","authenticated-orcid":false,"given":"Pallab","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics National Institute of Pharmaceutical Education and Research Kolkata (NIPER\u2010K)  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7074-1232","authenticated-orcid":false,"given":"Amit Kumar","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Chemical Science Unified Academic Campus Bose Institute  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4898-9797","authenticated-orcid":false,"given":"Abhijit","family":"Bera","sequence":"additional","affiliation":[{"name":"Department of Physics Midnapore College (Autonomous)  Midnapore West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9414-9740","authenticated-orcid":false,"given":"Jayanta","family":"Nanda","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of North Bengal Raja Rammohanpur Siliguri  Darjeeling West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521\u20103773(19991203)38:23<3418::AID\u2010ANIE3418>3.0.CO;2\u2010V"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a032540"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2204765119"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF01809580","article-title":"The Origin and Amplification of Biomolecular Chirality","volume":"21","author":"Bonner W. A.","year":"1991","journal-title":"Orig Life Evol Biosph"},{"key":"e_1_2_8_6_1","first-page":"1445","article-title":"The Origin and Amplification of Biomolecular Chirality","volume":"256","author":"Milton R. C. D.","year":"1992","journal-title":"Science"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr500671p"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00191K"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00476C"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00952A"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202308281"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200503142"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010026\u201071043\u20105"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202216447"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201061007\u20106"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201604833"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.23344"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2021.101469"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c10876"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b03502"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00354"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c00352"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.1c03988"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c07768"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c00804"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c12253"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1042\/BIO20210002"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.13.4398"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202510058"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1981"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/311019a0"},{"key":"e_1_2_8_32_1","first-page":"1","volume-title":"Topics in Stereochemistry","author":"Bonner W. A.","year":"1988"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202508481"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202315716"},{"key":"e_1_2_8_35_1","doi-asserted-by":"crossref","DOI":"10.1002\/syst.202400022","article-title":"Cysteine\u2010Based Dynamic Self\u2010Assembly and Their Importance in the Origins of Life","volume":"6","author":"Kuila S.","year":"2024","journal-title":"ChemSystemsChem"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/35057238"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010017\u201000463\u20101"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010017\u201002742\u20103"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b09755"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202404603"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3NR06752A"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c06041"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c14913"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2018.05.016"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.01.096"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CC01744D"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/la302583a"},{"key":"e_1_2_8_48_1","first-page":"122","article-title":"Antimicrobial Activity and Stability of the d\u2010Amino Acid Substituted Derivatives of Antimicrobial Peptide Polybia\u2010MPI","volume":"6","author":"Zhao Y.","year":"2016","journal-title":"Applied and Environmental Microbiology Express"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/psc.2989"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4NR00204K"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b07307"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep03875"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1sm05907f"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/cm300422q"},{"key":"e_1_2_8_55_1","first-page":"3516","article-title":"Chirality\u2010Match\u2010Directed Narcissistic Versus Social Self\u2010Sorting for Selective Excimer or Exciplex Circularly Polarized Luminescence","volume":"8","author":"Xu L.","year":"2026","journal-title":"Chinese Chemical Society Chemistry"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja301642c"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supmat.2025.100103"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c04872"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.100961"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9SC02239B"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201706162"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202308104"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c13598"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC03561D"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4OB01987C"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja4106545"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.2c06897"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.3c01273"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/asia.202400755"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202501718"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0MA00584C"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/la502799j"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1246\/bcsj.20090242"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202103071"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SM00584C"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1080\/00268976.2015.1025114"},{"key":"e_1_2_8_77_1","doi-asserted-by":"crossref","DOI":"10.1002\/wcms.1606","article-title":"Software Update: The ORCA Program System\u2014Version 5.0","volume":"12","author":"Neese F.","year":"2022","journal-title":"WIREs Computational Molecular Science"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.8b01176"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.1493"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0004608"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009\u20102614(00)00662\u2010X"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.70019"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.81"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.1c00471"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202405698"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja205345e"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00202K"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124005"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1098"},{"key":"e_1_2_8_90_1","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11249","article-title":"Plasmonic Piezoelectric Nanomechanical Resonator for Spectrally Selective Infrared Sensing","volume":"7","author":"Hui Y.","year":"2016","journal-title":"Nature Communications"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.0c00039"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202502787"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202501546"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.5c05506"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsaem.5c00269"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b01991"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.387221"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c20146"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c11727"},{"key":"e_1_2_8_100_1","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202515237","article-title":"Peptide Sequence Programmed Piezoelectric Response by Supramolecular Self\u2010Assembly","volume":"13","author":"Yang X.","year":"2026","journal-title":"Advanced Science"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c02993"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c06321"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.3c01232"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201022895\u20106"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.1859339","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.1859339","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.1859339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:56:44Z","timestamp":1789739804000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.1859339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":103,"alternative-id":["10.1002\/anie.1859339"],"URL":"https:\/\/doi.org\/10.1002\/anie.1859339","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,18]]},"assertion":[{"value":"2026-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1859339"}}