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Here, we report an aliphatic peptidomimetic polymer system whose luminescence is programmed through conformation\u2010directed hierarchical assembly. \u03b2\u2010sheet\u2010like and random\u2010coil conformations direct self\u2010assembly into rigid nanotubes and isotropic vesicles, respectively, with distinct emission profiles. At elevated local concentrations, the nanotubes undergo higher\u2010order assembly into spherical superstructures exhibiting a J\u2010aggregate\u2010like red\u2010shifted optical response, with a pronounced blue\u2010to\u2010orange color transition and emission extending into the near\u2010infrared region. We exploit this intrinsic concentration\u2010dependent color response for multicolor organelle imaging in living cells and for noninvasive, visually interpretable, semiquantitative mapping of polymer biodistribution in living animals. By converting local concentration into emission hue rather than absolute intensity, this work establishes a new design principle for self\u2010referenced optical imaging, with potential applications in biosensing, quantitative bioimaging, and drug delivery.<\/jats:p>","DOI":"10.1002\/anie.1895737","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:53:13Z","timestamp":1792133593000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peptidomimetic Polymer With Conformation\u2010Coded Hierarchical Assembly for Visualizing Biodistribution"],"prefix":"10.1002","author":[{"given":"Yeqiang","family":"Zhou","sequence":"first","affiliation":[{"name":"College of Polymer Science and Engineering National Key Laboratory of Advanced Polymer Materials Sichuan University  Chengdu 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