{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T21:37:29Z","timestamp":1766266649306},"reference-count":120,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,12,22]],"date-time":"2003-12-22T00:00:00Z","timestamp":1072051200000},"content-version":"vor","delay-in-days":11222,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angew. Chem. Int. Ed. Engl."],"published-print":{"date-parts":[[1973,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many cells have the ability to recognize and eliminate damage to their DNA, particularly thymine dimers formed by UV light. The elimination of this damage may be achieved by enzymatic, light\u2010dependent cleavage of the dimers into the monomers (photoreactivation) or more frequently by dark repair, in which the damaged part is completely removed from the, DNA. In this repair process, the DNA is incised by an endonuclease in the immediate vicinity of the thymine dimers. Oligonucleotides containing the thymine dimer are removed hydrolytically from the DNA by the 5\u21923\u2032 exonuclease activity of DNA polymerase I (Kornberg enzyme). The resulting gaps are immediately closed by a de novo synthesis with the aid of the same DNA polymerase I, the complementary strand serving as a template (excision repair). The final step is the formation of the phosphodiester bond between the newly synthesized DNA fragment and the old DNA strand by a DNA ligase. Xeroderma pigmentosum patients lack the endonuclease as a result of a genetic defect; they therefore cannot eliminate thymine dimers from their DNA, and are extremely sensitive to sunlight. All information so far suggests that genetic recombination and DNA repair are performed by the same enzyme system.<\/jats:p>","DOI":"10.1002\/anie.197302641","type":"journal-article","created":{"date-parts":[[2003,12,31]],"date-time":"2003-12-31T12:48:11Z","timestamp":1072874891000},"page":"264-273","source":"Crossref","is-referenced-by-count":9,"title":["Repair Processes on Deoxyribonucleic Acid"],"prefix":"10.1002","volume":"12","author":[{"given":"J.","family":"Berndt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,12,22]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(60)90063-9"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6603(08)60647-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.48.7.1250"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(63)90189-6"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.142.3598.1464"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.53.5.1111"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.37.070168.001135"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(66)80105-5"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(63)86806-X"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.35.2.73"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1128\/jb.58.4.511-522.1949","volume":"58","author":"Kelner A.","year":"1949","journal-title":"J. Bacteriol."},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1128\/br.22.2.99-142.1958","volume":"22","author":"Jagger J.","year":"1958","journal-title":"Bacteriol. Rev."},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.2307\/3583554"},{"key":"e_1_2_1_14_2","first-page":"341","volume-title":"The Chemical Basis of Heredity","author":"Goodgal S. H.","year":"1957"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.43.3.573"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1030580407"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.45.4.703"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.45.4.725"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(62)90181-X"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00800a025"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1030460207"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1965.tb07918.x"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4832-2781-8.50009-1"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.58.4.1359"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/2231066a0"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00753a014"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.2307\/3583553"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(58)90112-4"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-95117-6"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.48.12.2109"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.51.2.226"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.51.2.293"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)97573-3"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.56.3.932"},{"key":"e_1_2_1_35_2","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0021-9258(18)60378-3","volume":"237","author":"Lehmann J. R.","year":"1962","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(65)80064-X"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.62.3.934"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/2171110a0"},{"key":"e_1_2_1_39_2","doi-asserted-by":"crossref","first-page":"6182","DOI":"10.1016\/S0021-9258(18)63523-9","volume":"244","author":"Sadowsky P. D.","year":"1969","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.67.4.1839"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.67.1.434"},{"key":"e_1_2_1_42_2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0021-9258(19)45768-2","volume":"247","author":"Center M. S.","year":"1972","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.63.1.144"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.69.10.2927"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00794a001"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2787(71)90547-8"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/234047a0"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(70)90180-4"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)63556-2"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.36.070167.003241"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/224495a0"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.66.3.595"},{"key":"e_1_2_1_53_2","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1016\/S0021-9258(19)45263-0","volume":"247","author":"Miller L. K.","year":"1972","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.65.1.168"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(69)90228-9"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)45779-7"},{"key":"e_1_2_1_57_2","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0021-9258(19)45780-3","volume":"247","author":"Setlow P.","year":"1972","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)45781-5"},{"key":"e_1_2_1_59_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.163.3874.1410"},{"key":"e_1_2_1_60_2","doi-asserted-by":"publisher","DOI":"10.2307\/3583549"},{"key":"e_1_2_1_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0267-36"},{"key":"e_1_2_1_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/2241164a0"},{"key":"e_1_2_1_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/226711a0"},{"key":"e_1_2_1_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/226713a0"},{"key":"e_1_2_1_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(70)90770-9"},{"key":"e_1_2_1_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/226708a0"},{"key":"e_1_2_1_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/229081a0"},{"key":"e_1_2_1_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/229635a0"},{"key":"e_1_2_1_69_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.4.761"},{"key":"e_1_2_1_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/2281050a0"},{"key":"e_1_2_1_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(70)90566-8"},{"key":"e_1_2_1_72_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.12.3150"},{"key":"e_1_2_1_73_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.57.1.148"},{"key":"e_1_2_1_74_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.57.4.1021"},{"key":"e_1_2_1_75_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.57.5.1426"},{"key":"e_1_2_1_76_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.38.070169.004051"},{"key":"e_1_2_1_77_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.57.6.1700"},{"key":"e_1_2_1_78_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.57.6.1841"},{"key":"e_1_2_1_79_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.57.4.1021"},{"key":"e_1_2_1_80_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.58.5.1996"},{"key":"e_1_2_1_81_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.61.2.680"},{"key":"e_1_2_1_82_2","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1968.033.01.008"},{"key":"e_1_2_1_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)95807-2"},{"key":"e_1_2_1_84_2","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1016\/S0021-9258(18)93228-X","volume":"243","author":"Weiss B.","year":"1968","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_85_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.10.2559"},{"key":"e_1_2_1_86_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.63.3.904"},{"key":"e_1_2_1_87_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.61.1.237"},{"key":"e_1_2_1_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)93227-8"},{"key":"e_1_2_1_89_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.65.3.652"},{"key":"e_1_2_1_90_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.69.10.3009"},{"key":"e_1_2_1_91_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.67.3.1468"},{"key":"e_1_2_1_92_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.60.4.1495"},{"key":"e_1_2_1_93_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.64.4.1195"},{"key":"e_1_2_1_94_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.67.3.1580"},{"key":"e_1_2_1_95_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.5.1002"},{"key":"e_1_2_1_96_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.12.2967"},{"key":"e_1_2_1_97_2","doi-asserted-by":"publisher","DOI":"10.1038\/214790a0"},{"key":"e_1_2_1_98_2","doi-asserted-by":"publisher","DOI":"10.1038\/newbio240114a0"},{"key":"e_1_2_1_99_2","doi-asserted-by":"publisher","DOI":"10.1080\/09553006914551281"},{"key":"e_1_2_1_100_2","doi-asserted-by":"publisher","DOI":"10.1080\/09553007014550821"},{"key":"e_1_2_1_101_2","doi-asserted-by":"publisher","DOI":"10.1038\/218970a0"},{"key":"e_1_2_1_102_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.165.3892.490"},{"key":"e_1_2_1_103_2","doi-asserted-by":"publisher","DOI":"10.1038\/216369a0"},{"key":"e_1_2_1_104_2","doi-asserted-by":"publisher","DOI":"10.1038\/218489b0"},{"key":"e_1_2_1_105_2","doi-asserted-by":"publisher","DOI":"10.1080\/09553007014550911"},{"key":"e_1_2_1_106_2","doi-asserted-by":"publisher","DOI":"10.1038\/224804a0"},{"key":"e_1_2_1_107_2","doi-asserted-by":"publisher","DOI":"10.2307\/3573178"},{"key":"e_1_2_1_108_2","doi-asserted-by":"publisher","DOI":"10.1080\/09553007214551301"},{"key":"e_1_2_1_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(72)90399-3"},{"key":"e_1_2_1_110_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1971.tb01257.x"},{"key":"e_1_2_1_111_2","doi-asserted-by":"publisher","DOI":"10.1038\/218652a0"},{"key":"e_1_2_1_112_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.63.2.428"},{"key":"e_1_2_1_113_2","doi-asserted-by":"publisher","DOI":"10.1080\/09553007014551491"},{"key":"e_1_2_1_114_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.64.3.1035"},{"key":"e_1_2_1_115_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.4.708"},{"key":"e_1_2_1_116_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.67.1.434"},{"key":"e_1_2_1_117_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.7.1639"},{"key":"e_1_2_1_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(71)90376-7"},{"key":"e_1_2_1_119_2","first-page":"1150","volume":"69","author":"Cooper P. K.","year":"1972","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"e_1_2_1_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(71)90377-9"}],"container-title":["Angewandte Chemie International Edition in English"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fanie.197302641","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.197302641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T18:31:24Z","timestamp":1697740284000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.197302641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,4]]},"references-count":120,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1973,4]]}},"alternative-id":["10.1002\/anie.197302641"],"URL":"https:\/\/doi.org\/10.1002\/anie.197302641","archive":["Portico"],"relation":{},"ISSN":["0570-0833"],"issn-type":[{"value":"0570-0833","type":"print"}],"subject":[],"published":{"date-parts":[[1973,4]]}}}