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However, it remains largely confined to homogeneous systems, where catalyst recovery and reuse are often challenging. Here, we report a recyclable gold single\u2010atom catalyst (SAC) supported on activated carbon (AC) for the selective shuttle hydrochlorination of terminal alkynes to vinyl chlorides, which are key intermediates in pharmaceutical synthesis. Spectroscopic and catalytic studies indicate that the combination of Au(I) single atoms with the AC carrier is essential for the unique chemo\u2010 and stereoselectivity observed. This heterogeneous system displays broad substrate compatibility, including sterically hindered alkynes, heterocycles, acid\u2010labile groups, and drug\u2010derived substrates. Upon reuse, gradual aggregation of gold single atoms into nanoparticles leads to activity losses, but the associated speciation changes are reversible by oxidative redispersion, while quantitative metal retention ensures recoverability. Overall, this study demonstrates how to extend heterogeneous SACs to shuttle catalysis, highlighting the complementary reactivity and distinct catalyst design requirements for developing recoverable, safer, and more sustainable heterogeneous transfer reactions.<\/jats:p>","DOI":"10.1002\/anie.1983055","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:15:16Z","timestamp":1791800116000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gold Single\u2010Atom Catalysts Enable Selective Shuttle Hydrochlorination of Alkynes"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9874-2736","authenticated-orcid":false,"given":"Marc\u2010Eduard","family":"Usteri","sequence":"first","affiliation":[{"name":"Institute of Chemical and Bioengineering ETH Zurich  Zurich Switzerland"},{"name":"NCCR Catalysis Zurich 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