{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:50:12Z","timestamp":1790495412034,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2009,4,27]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Many components make light work<\/jats:bold>: A novel synthetic strategy for the preparation of pyridines and isoquinolines in high chemo\u2010 and regioselectivity has been developed. By manipulating the reaction conditions, either product can be generated smoothly in a highly efficient and atom\u2010economic manner (see scheme).<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/gif\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/mcontent.gif\"><jats:alt-text>magnified image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1002\/anie.200900212","type":"journal-article","created":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T14:04:28Z","timestamp":1239026668000},"page":"3458-3461","source":"Crossref","is-referenced-by-count":200,"title":["A Multicomponent Reaction of Arynes, Isocyanides, and Terminal Alkynes: Highly Chemo\u2010 and Regioselective Synthesis of Polysubstituted Pyridines and Isoquinolines"],"prefix":"10.1002","volume":"48","author":[{"given":"Feng","family":"Sha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,4,23]]},"reference":[{"key":"e_1_2_3_1_2","unstructured":"\u00a0"},{"key":"e_1_2_3_2_2","volume-title":"The Chemistry of Hetrocyclic Compounds","year":"1981"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1039\/b409720n"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1039\/b413750g"},{"key":"e_1_2_3_5_2","unstructured":"\u00a0"},{"key":"e_1_2_3_6_2","first-page":"407","volume-title":"Pharmaceutical Chemistry, Drug Synthesis, Vol.\u20051","year":"1988"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm980550w"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2004.01.021"},{"key":"e_1_2_3_9_2","unstructured":"\u00a0"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2005.04.139"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1039\/B513222C"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo0267955"},{"key":"e_1_2_3_13_2","unstructured":"\u00a0"},{"key":"e_1_2_3_14_2","volume-title":"Organic Reactions, Vol.\u20056","author":"Whaley W. M.","year":"1951"},{"key":"e_1_2_3_15_2","volume-title":"Comprehensive Heterocyclic Chemistry II, Vol.\u20055","author":"Jones G.","year":"1996"},{"key":"e_1_2_3_16_2","unstructured":"\u00a0"},{"key":"e_1_2_3_17_2","volume-title":"Progress in Heterocyclic Chemistry, Vol.\u200514","author":"Coffey D. S.","year":"2002"},{"key":"e_1_2_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2004.04.043"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr030677f"},{"key":"e_1_2_3_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo0261303"},{"key":"e_1_2_3_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol034192p"},{"key":"e_1_2_3_22_2","unstructured":"\u00a0"},{"key":"e_1_2_3_23_2","volume-title":"Dehydrobenzene and Cycloalkynes","author":"Hoffmann R. W.","year":"1967"},{"key":"e_1_2_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-052349-1.00101-3"},{"key":"e_1_2_3_25_2","volume-title":"The Chemistry of Triple\u2010Bonded Functional Groups, Supplement\u2005C2","author":"Hart H.","year":"1994"},{"key":"e_1_2_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200390119"},{"key":"e_1_2_3_26_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200390151"},{"key":"e_1_2_3_27_2","unstructured":"\u00a0"},{"key":"e_1_2_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)95372-9"},{"key":"e_1_2_3_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar00164a003"},{"key":"e_1_2_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3757(20020902)114:17<3381::AID-ANGE3381>3.0.CO;2-C"},{"key":"e_1_2_3_30_3","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20020902)41:17<3247::AID-ANIE3247>3.0.CO;2-P"},{"key":"e_1_2_3_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja064157o"},{"key":"e_1_2_3_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo702062n"},{"key":"e_1_2_3_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja0780582"},{"key":"e_1_2_3_34_2","unstructured":"\u00a0"},{"key":"e_1_2_3_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200460009"},{"key":"e_1_2_3_35_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200460009"},{"key":"e_1_2_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2004.09.144"},{"key":"e_1_2_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2007.03.042"},{"key":"e_1_2_3_38_2","unstructured":"\u00a0"},{"key":"e_1_2_3_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/cber.19650981233"},{"key":"e_1_2_3_40_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo980929q"},{"key":"e_1_2_3_41_2","unstructured":"The resulting aryl anion is available to abstract a proton thus leading to the formation of monosubstituted arenes. For examples see:"},{"key":"e_1_2_3_42_2","doi-asserted-by":"publisher","DOI":"10.1039\/b602664h"},{"key":"e_1_2_3_43_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo0602221"},{"key":"e_1_2_3_44_2","unstructured":"For the reactions of azabutadienes to form azaheterocycles through [4+2]\u2005cycloaddition see:"},{"key":"e_1_2_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-091697-2.50012-3"},{"key":"e_1_2_3_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-0690(200110)2001:19<3587::AID-EJOC3587>3.0.CO;2-5"},{"key":"e_1_2_3_47_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja060626a"},{"key":"e_1_2_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2006.03.051"},{"key":"e_1_2_3_49_2","unstructured":"\u00a0"},{"key":"e_1_2_3_50_2","doi-asserted-by":"publisher","DOI":"10.1246\/cl.1983.1211"},{"key":"e_1_2_3_51_2","first-page":"1454","author":"Pe\u00f1a D.","year":"2002","journal-title":"Synthesis"},{"key":"e_1_2_3_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200700101"},{"key":"e_1_2_3_52_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200700101"},{"key":"e_1_2_3_53_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo0619534"},{"key":"e_1_2_3_54_2","unstructured":"Preferential nucleophilic attack at thepara\u2005position to a chlorine atom also occurred in nucleophilic reactions withp\u2010chloroaryne:"},{"key":"e_1_2_3_55_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo01259a001"},{"key":"e_1_2_3_56_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00788a026"},{"key":"e_1_2_3_57_2","unstructured":"CCDC\u2005715782 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre viawww.ccdc.cam.ac.uk\/data_request\/cif."}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fanie.200900212","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.200900212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T21:51:45Z","timestamp":1695937905000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.200900212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,23]]},"references-count":61,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2009,4,27]]}},"alternative-id":["10.1002\/anie.200900212"],"URL":"https:\/\/doi.org\/10.1002\/anie.200900212","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,23]]}}}