{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:20:30Z","timestamp":1790515230529,"version":"4.1.0"},"reference-count":269,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T00:00:00Z","timestamp":1372291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2013,7,29]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>After malaria, schistosomiasis (or bilharzia) is the second most prevalent disease in Africa, and is occurring in over 70\u2005countries in tropical and subtropical regions. It is estimated that 600\u2005million people are at risk of infection, 200\u2005million people are infected, and at least 200\u2009000 deaths per year are associated with the disease. All schistosome species are transmitted through contact with fresh water that is infested with free\u2010swimming forms of the parasite, which is known as cercariae and produced by snails. When located in the blood vessels of the host, larval and adult schistosomes digest red cells to acquire amino acids for growth and development. Vaccine candidates have been unsuccessful up to now. Against such devastating parasitic disease, the antischistosomal arsenal is currently limited to a single drug, praziquantel, which has been used for more than 35\u2005years. Because the question of the reduction of the activity of praziquantel was raised recently, it is thus urgent to create new and safe antischistosomal drugs that should be combined with praziquantel to develop efficient bitherapies.<\/jats:p>","DOI":"10.1002\/anie.201208390","type":"journal-article","created":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T13:02:16Z","timestamp":1372338136000},"page":"7936-7956","source":"Crossref","is-referenced-by-count":118,"title":["Schistosomiasis Chemotherapy"],"prefix":"10.1002","volume":"52","author":[{"given":"Sophie A.\u2010L.","family":"Th\u00e9tiot\u2010Laurent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Boissier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Robert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Meunier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,27]]},"reference":[{"key":"e_1_2_8_1_2","first-page":"1730","volume":"104","author":"Von Schadewaldt H.","year":"1962","journal-title":"Munch. Med. Wochenschr."},{"key":"e_1_2_8_2_2","unstructured":"Rev. Infect. Dis.1982 4 727\u2013732. (Excerpts of the translation of the original letters of T. Bilharz to C.\u2005T. von\u2005Siebold published in: Ein Beitrag zur Helminthographia humana."},{"key":"e_1_2_8_2_3","unstructured":"Z. Wiss. Zool.1853 4 53\u201376 and"},{"key":"e_1_2_8_2_4","unstructured":"Z. Wiss. Zool.1853 4 453\u2013456;"},{"key":"e_1_2_8_2_5","unstructured":"The volume is available free of charge athttp:\/\/books.google.fr\/books?id=DwMXAAAAYAAJ&printsec=frontcover&hl=fr&ie=ISO\u20108859\u20101#v=onepage&q&f=false. January 7 2013)."},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(00)00122-4"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(05)61013-5"},{"key":"e_1_2_8_5_2","unstructured":"\u00a0"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69440-3"},{"key":"e_1_2_8_7_2","unstructured":"D. Rollinson S. Knopp S. Levitz J.\u2005R. Stothard L.\u2010A. Tchuem Tchuent\u00e9 A. Garba K.\u2005A. Mohammed N. Schur B. Person D.\u2005G. Colley J. Utzinger Acta Trop.DOI:;"},{"key":"e_1_2_8_8_2","unstructured":"WHO Fact sheet No. 115 January2012; Document available athttp:\/\/www.who.int\/mediacentre\/factsheets\/fs115\/en\/index.html; October 12 2012."},{"key":"e_1_2_8_9_2","first-page":"190","volume":"81","author":"Ferrari M. L. A.","year":"2003","journal-title":"Bull. W. H. O."},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66457-4"},{"key":"e_1_2_8_11_2","first-page":"1504","volume":"13","author":"Deganello R.","year":"2007","journal-title":"Emerging Infect. Dis."},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2005.07.026"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2005.07.005"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.05.025031"},{"key":"e_1_2_8_15_2","unstructured":"Report no. 44466 from The World Bank June 25 2008. Document available athttp:\/\/siteresources.worldbank.org\/EXTWBASSHEANUTPOP\/Resources\/egypt_schistosomiasis_ppar.pdf. Sept. 12 2012."},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762007000800019"},{"key":"e_1_2_8_17_2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.4269\/ajtmh.2008.78.140","volume":"78","author":"Enk M. J.","year":"2008","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2007.12.002"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(00)00141-7"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2004.11.003"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2006.08.004"},{"key":"e_1_2_8_22_2","unstructured":"\u00a0"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra012396"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8305.2010.00433.x"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60231-6"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2006.06.011"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2007.77.866"},{"key":"e_1_2_8_28_2","volume-title":"General Parasitology, 2nd\u2005ed.","author":"Cheng T. C.","year":"1986"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1179\/136485907X193833"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2004.12.003"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.2307\/3274873"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(61)90026-1"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182006001648"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.2.3.250"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2007.08.004"},{"key":"e_1_2_8_36_2","unstructured":"\u00a0"},{"key":"e_1_2_8_37_2","doi-asserted-by":"crossref","first-page":"964","DOI":"10.4269\/ajtmh.2007.76.964","volume":"76","author":"Jaur\u00e9guiberry S.","year":"2007","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2007.02.026"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02725.x"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2001.65.852"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2001.01446.x"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2004.04.002"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.2307\/3277456"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(78)90066-8"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(97)00098-4"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.2307\/3278572"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1959.tb00930.x"},{"key":"e_1_2_8_48_2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4269\/ajtmh.1966.15.28","volume":"15","author":"Kloetze K.","year":"1966","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.4.961"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01786-5"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00031382"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.2307\/3226097"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(00)00299-1"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/0305-0491(72)90135-6"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)47761-7"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.2.713"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(00)00365-0"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.09.035"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.2.325"},{"key":"e_1_2_8_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/35005132"},{"key":"e_1_2_8_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00239-07"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.03.054"},{"key":"e_1_2_8_63_2","unstructured":"\u00a0"},{"key":"e_1_2_8_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(97)01207-6"},{"key":"e_1_2_8_65_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762006000900004"},{"key":"e_1_2_8_66_2","unstructured":"\u00a0"},{"key":"e_1_2_8_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(63)90063-8"},{"key":"e_1_2_8_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(95)80041-7"},{"key":"e_1_2_8_69_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir545"},{"key":"e_1_2_8_70_2","unstructured":"\u00a0"},{"key":"e_1_2_8_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2005.01.003"},{"key":"e_1_2_8_72_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001704"},{"key":"e_1_2_8_73_2","unstructured":"http:\/\/clinicaltrials.gov\/ct2\/show\/NCT00870649."},{"key":"e_1_2_8_74_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00046-07"},{"key":"e_1_2_8_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)02807-0"},{"key":"e_1_2_8_76_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1955.4.1049"},{"key":"e_1_2_8_77_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1964.03060340059019"},{"key":"e_1_2_8_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(95)00026-7"},{"key":"e_1_2_8_79_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-006-0175-2"},{"key":"e_1_2_8_80_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02783753"},{"key":"e_1_2_8_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(03)00125-X"},{"key":"e_1_2_8_82_2","unstructured":"R. D. S.Milan C. P.Demichele F. J. G.Frezard A. L.Demelo L. A. M.Ferreira R. O.Bejarano P. C. T. Int. Appl.2006 WO 2006000069."},{"key":"e_1_2_8_83_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1957.tb00114.x"},{"key":"e_1_2_8_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(66)90285-1"},{"key":"e_1_2_8_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(79)90001-7"},{"key":"e_1_2_8_86_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1954.tb00861.x"},{"key":"e_1_2_8_87_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.2686.1424"},{"key":"e_1_2_8_88_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.2695.405"},{"key":"e_1_2_8_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(19)90009-5"},{"key":"e_1_2_8_90_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.3223.661-d"},{"key":"e_1_2_8_91_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.2968.645"},{"key":"e_1_2_8_92_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1947.00220080116006"},{"key":"e_1_2_8_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(55)90169-1"},{"key":"e_1_2_8_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(65)90013-1"},{"key":"e_1_2_8_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(67)90109-5"},{"key":"e_1_2_8_96_2","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1016\/S0021-9258(17)34786-5","volume":"253","author":"Gupta R. S.","year":"1978","journal-title":"J. Biol. Chem."},{"key":"e_1_2_8_97_2","doi-asserted-by":"publisher","DOI":"10.2307\/3276469"},{"key":"e_1_2_8_98_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00313a006"},{"key":"e_1_2_8_99_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/149.4.615"},{"key":"e_1_2_8_100_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.5.2.263"},{"key":"e_1_2_8_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(87)90057-9"},{"key":"e_1_2_8_102_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0606.000606"},{"key":"e_1_2_8_103_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00351767"},{"key":"e_1_2_8_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(71)90070-8"},{"key":"e_1_2_8_105_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000068244"},{"key":"e_1_2_8_106_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1981.tb03260.x"},{"key":"e_1_2_8_107_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v60n0510"},{"key":"e_1_2_8_108_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.19660781805"},{"key":"e_1_2_8_108_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.196608571"},{"key":"e_1_2_8_109_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/14.1.31"},{"key":"e_1_2_8_110_2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/00034983.1971.11686729","volume":"65","author":"Foster R.","year":"1971","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"e_1_2_8_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)92894-2"},{"key":"e_1_2_8_112_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1969.tb15886.x"},{"key":"e_1_2_8_113_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1969.tb15902.x"},{"key":"e_1_2_8_114_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5482.276"},{"key":"e_1_2_8_115_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1969.tb15879.x"},{"key":"e_1_2_8_116_2","first-page":"291","volume":"24","author":"Tracy J. W.","year":"1983","journal-title":"Mol. Pharmacol."},{"key":"e_1_2_8_117_2","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.4049\/jimmunol.115.5.1414","volume":"115","author":"Daniels J. C.","year":"1975","journal-title":"J. Immunol."},{"key":"e_1_2_8_118_2","first-page":"4599","volume":"40","author":"Blumer J. L.","year":"1980","journal-title":"Cancer Res."},{"key":"e_1_2_8_119_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01920794"},{"key":"e_1_2_8_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(89)90530-3"},{"key":"e_1_2_8_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(91)90267-9"},{"key":"e_1_2_8_122_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840030608"},{"key":"e_1_2_8_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(90)90396-3"},{"key":"e_1_2_8_124_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(91)90532-A"},{"key":"e_1_2_8_125_2","first-page":"469","volume":"45","author":"Clapper M. L.","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"e_1_2_8_126_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2005.73.365"},{"key":"e_1_2_8_127_2","doi-asserted-by":"publisher","DOI":"10.26719\/2010.16.9.932"},{"key":"e_1_2_8_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(90)90009-2"},{"key":"e_1_2_8_129_2","first-page":"57","volume":"53","author":"Guirguis F. R.","year":"2003","journal-title":"Arzneim.\u2010Forsch."},{"key":"e_1_2_8_130_2","unstructured":"http:\/\/whqlibdoc.who.int\/hq\/2011\/a95053_eng.pdf. July 16th 2012."},{"key":"e_1_2_8_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(47)90919-7"},{"key":"e_1_2_8_132_2","doi-asserted-by":"crossref","first-page":"220","DOI":"10.4269\/ajtmh.1980.29.220","volume":"29","author":"Cioli D.","year":"1980","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"e_1_2_8_133_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00317a025"},{"key":"e_1_2_8_134_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.172.3987.1058"},{"key":"e_1_2_8_135_2","doi-asserted-by":"publisher","DOI":"10.1038\/239107a0"},{"key":"e_1_2_8_136_2","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0022-3565(25)29613-6","volume":"186","author":"Haese W. H.","year":"1973","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_8_137_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.17.7754"},{"key":"e_1_2_8_138_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.172.3987.1057"},{"key":"e_1_2_8_139_2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4269\/ajtmh.1985.34.112","volume":"34","author":"Pica\u2010Mattoccia L.","year":"1985","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"e_1_2_8_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91721-6"},{"key":"e_1_2_8_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(02)90405-0"},{"key":"e_1_2_8_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(78)90051-2"},{"key":"e_1_2_8_143_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(82)90235-8"},{"key":"e_1_2_8_144_2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.4269\/ajtmh.1975.24.827","volume":"24","author":"Hillman G. R.","year":"1975","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"e_1_2_8_145_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(83)90002-6"},{"key":"e_1_2_8_146_2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4269\/ajtmh.1985.34.112","volume":"34","author":"Pica\u2010Mattochia L.","year":"1985","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"e_1_2_8_147_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(89)90508-7"},{"key":"e_1_2_8_148_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762006000900048"},{"key":"e_1_2_8_149_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(99)00221-X"},{"key":"e_1_2_8_150_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023679"},{"key":"e_1_2_8_151_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(78)90018-4"},{"key":"e_1_2_8_152_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00374-5"},{"key":"e_1_2_8_153_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.151324"},{"key":"e_1_2_8_154_2","doi-asserted-by":"publisher","DOI":"10.1002\/chir.530020413"},{"key":"e_1_2_8_155_2","doi-asserted-by":"publisher","DOI":"10.1016\/0731-7085(89)80189-X"},{"key":"e_1_2_8_156_2","first-page":"555","volume":"31","author":"Frohberg H.","year":"1981","journal-title":"Arzneim.\u2010Forsch."},{"key":"e_1_2_8_157_2","first-page":"1137","volume":"34","author":"Frohberg H.","year":"1984","journal-title":"Arzneim.\u2010Forsch."},{"key":"e_1_2_8_158_2","unstructured":"http:\/\/www.merckgroup.com\/en\/responsibility\/society\/global_responsibility_projects\/praziquantel.html. July 18th 2012."},{"key":"e_1_2_8_159_2","unstructured":"http:\/\/apps.who.int\/medicinedocs\/pdf\/whozip48e\/whozip48e.pdf."},{"key":"e_1_2_8_160_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.10.2903-2904.2000"},{"key":"e_1_2_8_161_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.2610030204"},{"key":"e_1_2_8_162_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/159.3.589"},{"key":"e_1_2_8_163_2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.4269\/ajtmh.1991.45.345","volume":"45","author":"Wu M.\u2010H.","year":"1991","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"e_1_2_8_164_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(92)80425-P"},{"key":"e_1_2_8_165_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00560463"},{"key":"e_1_2_8_166_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/151.6.1130"},{"key":"e_1_2_8_167_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2003.12.003"},{"key":"e_1_2_8_168_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001474"},{"key":"e_1_2_8_169_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(96)80640-5"},{"key":"e_1_2_8_170_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000051568"},{"key":"e_1_2_8_171_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(85)90041-4"},{"key":"e_1_2_8_172_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(89)90001-7"},{"key":"e_1_2_8_173_2","unstructured":"\u00a0"},{"key":"e_1_2_8_174_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00507974"},{"key":"e_1_2_8_175_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2004.09.004"},{"key":"e_1_2_8_176_2","unstructured":"\u00a0"},{"key":"e_1_2_8_177_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C100273200"},{"key":"e_1_2_8_178_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2006.02.002"},{"key":"e_1_2_8_179_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182005008346"},{"key":"e_1_2_8_180_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762001000900012"},{"key":"e_1_2_8_181_2","first-page":"1051","volume":"251","author":"Thompson D. P.","year":"1986","journal-title":"Am. J. Physiol."},{"key":"e_1_2_8_182_2","doi-asserted-by":"publisher","DOI":"10.1645\/GE-2586.1"},{"key":"e_1_2_8_183_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000077398"},{"key":"e_1_2_8_184_2","doi-asserted-by":"publisher","DOI":"10.1038\/333076a0"},{"key":"e_1_2_8_185_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2006.09.017"},{"key":"e_1_2_8_186_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01222-08"},{"key":"e_1_2_8_187_2","unstructured":"\u00a0"},{"key":"e_1_2_8_188_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1994.51.83"},{"key":"e_1_2_8_189_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-012-3151-z"},{"key":"e_1_2_8_190_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1996.55.214"},{"key":"e_1_2_8_191_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.61.760"},{"key":"e_1_2_8_192_2","doi-asserted-by":"crossref","first-page":"509","DOI":"10.4269\/ajtmh.1991.44.509","volume":"44","author":"Katz N.","year":"1991","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"e_1_2_8_193_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.2001.00811.x"},{"key":"e_1_2_8_194_2","doi-asserted-by":"crossref","first-page":"342","DOI":"10.4269\/ajtmh.2006.74.342","volume":"74","author":"Alonso D.","year":"2006","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"e_1_2_8_195_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2012.11-0701"},{"key":"e_1_2_8_196_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2010.05.003"},{"key":"e_1_2_8_197_2","first-page":"280","volume":"13","author":"You J.\u2010Q.","year":"1992","journal-title":"Acta Pharmacol. Sin."},{"key":"e_1_2_8_198_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.9.1557"},{"key":"e_1_2_8_199_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(75)90016-8"},{"key":"e_1_2_8_200_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(00)00091-6"},{"key":"e_1_2_8_201_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(02)90110-0"},{"key":"e_1_2_8_202_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2005.07.013"},{"key":"e_1_2_8_203_2","unstructured":"\u00a0"},{"key":"e_1_2_8_204_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02114-0"},{"key":"e_1_2_8_205_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(00)90453-X"},{"key":"e_1_2_8_206_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2006.03.003"},{"key":"e_1_2_8_207_2","doi-asserted-by":"publisher","DOI":"10.1086\/651682"},{"key":"e_1_2_8_208_2","doi-asserted-by":"publisher","DOI":"10.1179\/136485908X252214"},{"key":"e_1_2_8_209_2","doi-asserted-by":"publisher","DOI":"10.1086\/324004"},{"key":"e_1_2_8_210_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70161-4"},{"key":"e_1_2_8_211_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70169-9"},{"key":"e_1_2_8_212_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-010-1944-5"},{"key":"e_1_2_8_213_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-011-2641-8"},{"key":"e_1_2_8_214_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201107446"},{"key":"e_1_2_8_214_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201107446"},{"key":"e_1_2_8_215_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(01)00138-3"},{"key":"e_1_2_8_216_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.2000.00628.x"},{"key":"e_1_2_8_217_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500972102"},{"key":"e_1_2_8_218_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar100070k"},{"key":"e_1_2_8_219_2","unstructured":"\u00a0"},{"key":"e_1_2_8_220_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(01)90336-0"},{"key":"e_1_2_8_221_2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00436-002-0786-1","volume":"89","author":"Xiao S.\u2010H.","year":"2003","journal-title":"Parasitol. Res."},{"key":"e_1_2_8_222_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4894(02)00145-5"},{"key":"e_1_2_8_223_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2011.03.006"},{"key":"e_1_2_8_224_2","first-page":"478","volume":"12","author":"Yin J.\u2010W.","year":"1991","journal-title":"Acta Pharmacol. Sin."},{"key":"e_1_2_8_225_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2005.12.001"},{"key":"e_1_2_8_226_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(01)00187-5"},{"key":"e_1_2_8_227_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-008-1227-6"},{"key":"e_1_2_8_228_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2007.08.007"},{"key":"e_1_2_8_229_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2005.00764.x"},{"key":"e_1_2_8_230_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm9902180"},{"key":"e_1_2_8_231_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000350"},{"key":"e_1_2_8_232_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762011000700006"},{"key":"e_1_2_8_233_2","unstructured":"\u00a0"},{"key":"e_1_2_8_234_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182009990965"},{"key":"e_1_2_8_235_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2010.08.008"},{"key":"e_1_2_8_236_2","first-page":"93","volume":"22","author":"Fu S.","year":"1986","journal-title":"Br. J. Clin. Pharmacol."},{"key":"e_1_2_8_237_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2010.08.011"},{"key":"e_1_2_8_238_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-010-1782-5"},{"key":"e_1_2_8_239_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2007.03.006"},{"key":"e_1_2_8_240_2","unstructured":"\u00a0"},{"key":"e_1_2_8_241_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201100167"},{"key":"e_1_2_8_242_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-011-2267-x"},{"key":"e_1_2_8_243_2","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2011.625952"},{"key":"e_1_2_8_244_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040206"},{"key":"e_1_2_8_245_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1737"},{"key":"e_1_2_8_246_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm901021k"},{"key":"e_1_2_8_247_2","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.200590229"},{"key":"e_1_2_8_248_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02779"},{"key":"e_1_2_8_249_2","unstructured":"J. L.Vennerstrom Y.Dong J.Chollet H.Matile M.Padmaniyalam Y.Tang W. N.Charman Patent US 2004\/01 861 68 A1."},{"key":"e_1_2_8_250_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01537-06"},{"key":"e_1_2_8_251_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200700975"},{"key":"e_1_2_8_252_2","doi-asserted-by":"publisher","DOI":"10.1002\/1439-7633(20001117)1:4<281::AID-CBIC281>3.0.CO;2-W"},{"key":"e_1_2_8_253_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00967-06"},{"key":"e_1_2_8_254_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804338105"},{"key":"e_1_2_8_255_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar7000843"},{"key":"e_1_2_8_256_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar990164o"},{"key":"e_1_2_8_257_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar100070k"},{"key":"e_1_2_8_258_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00165-08"},{"key":"e_1_2_8_259_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00640-09"},{"key":"e_1_2_8_260_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00082-11"},{"key":"e_1_2_8_261_2","doi-asserted-by":"publisher","DOI":"10.2307\/3282599"},{"key":"e_1_2_8_262_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M511148200"},{"key":"e_1_2_8_263_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(92)90221-5"},{"key":"e_1_2_8_264_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2007.08.018"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fanie.201208390","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.201208390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T12:36:55Z","timestamp":1746016615000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201208390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,27]]},"references-count":269,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2013,7,29]]}},"alternative-id":["10.1002\/anie.201208390"],"URL":"https:\/\/doi.org\/10.1002\/anie.201208390","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,27]]}}}