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In pursuit of a sustainable supply, we report a highly stereocontrolled total synthesis (3.2\u2009% yield) based on a convergent sequence of palladium\u2010mediated fragment assembly and macrolactonization. Boron\u2010mediated aldol reactions were used to configure the three key fragments <jats:bold>2<\/jats:bold>, <jats:bold>5<\/jats:bold>, and <jats:bold>6<\/jats:bold> by employing the appropriate enantiomer of the lactate\u2010derived ketone <jats:bold>7<\/jats:bold>.<\/jats:p>","DOI":"10.1002\/anie.201310164","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T13:30:42Z","timestamp":1391088642000},"page":"2692-2695","source":"Crossref","is-referenced-by-count":38,"title":["Total Synthesis of the Antimitotic Marine Macrolide (\u2212)\u2010Leiodermatolide"],"prefix":"10.1002","volume":"53","author":[{"given":"Ian","family":"Paterson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth K.\u2010H.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Millican","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Dalby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,30]]},"reference":[{"key":"e_1_2_2_1_2","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1039\/B515619J"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1201\/9781420039658.ch26"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1054\/drup.2002.0230"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209124"},{"key":"e_1_2_2_5_3","first-page":"2442","volume":"368","author":"Verma S.","year":"2013","journal-title":"N. 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