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Over the past several decades, remarkable progress has been made in the development and application of engineered nanoparticles to treat cancer more effectively. For example, therapeutic agents have been integrated with nanoparticles engineered with optimal sizes, shapes, and surface properties to increase their solubility, prolong their circulation half\u2010life, improve their biodistribution, and reduce their immunogenicity. Nanoparticles and their payloads have also been favorably delivered into tumors by taking advantage of the pathophysiological conditions, such as the enhanced permeability and retention effect, and the spatial variations in the pH\u2005value. Additionally, targeting ligands (e.g., small organic molecules, peptides, antibodies, and nucleic acids) have been added to the surface of nanoparticles to specifically target cancerous cells through selective binding to the receptors overexpressed on their surface. Furthermore, it has been demonstrated that multiple types of therapeutic drugs and\/or diagnostic agents (e.g., contrast agents) could be delivered through the same carrier to enable combination therapy with a potential to overcome multidrug resistance, and real\u2010time readout on the treatment efficacy. It is anticipated that precisely engineered nanoparticles will emerge as the next\u2010generation platform for cancer therapy and many other biomedical applications.<\/jats:p>","DOI":"10.1002\/anie.201403036","type":"journal-article","created":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T16:43:37Z","timestamp":1412700217000},"page":"12320-12364","source":"Crossref","is-referenced-by-count":2042,"title":["Engineered Nanoparticles for Drug Delivery in Cancer Therapy"],"prefix":"10.1002","volume":"53","author":[{"given":"Tianmeng","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Shrike","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Choon","family":"Hyun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaoxin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Younan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,7]]},"reference":[{"key":"e_1_2_8_1_2","unstructured":"Globocan 2012 IARC2013."},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2012.12.006"},{"key":"e_1_2_8_3_2","unstructured":"Latest world cancer statistics IARC2013."},{"key":"e_1_2_8_4_2","unstructured":"American Cancer Society2013."},{"key":"e_1_2_8_5_2","first-page":"318","volume":"4","author":"Aruna U.","year":"2013","journal-title":"Inter. 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