{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:10:03Z","timestamp":1789884603518,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"26","license":[{"start":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T00:00:00Z","timestamp":1400630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2014,6,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We have developed an activatable photosensitizer capable of specifically inducing the death of \u03b2\u2010galactosidase\u2010expressing cells in response to photoirradiation. By using a selenium\u2010substituted rhodol scaffold bearing \u03b2\u2010galactoside as a targeting substituent, we designed and synthesized HMDESeR\u2010\u03b2Gal, which has a non\u2010phototoxic spirocyclic structure owing to the presence of the galactoside moiety. However, \u03b2\u2010galactosidase efficiently converted HMDESeR\u2010\u03b2Gal into phototoxic HMDESeR, which exists predominantly in the open xanthene form. This structural change resulted in drastic recovery of visible\u2010wavelength absorption and the ability to generate singlet oxygen (\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ). When HMDESeR\u2010\u03b2Gal was applied to larval\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    wing disks, which express \u03b2\u2010galactosidase only in the posterior region, photoirradiation induced cell death in the \u03b2\u2010galactosidase\u2010expressing region with high specificity.\n                  <\/jats:p>","DOI":"10.1002\/anie.201403221","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T16:26:53Z","timestamp":1400689613000},"page":"6772-6775","source":"Crossref","is-referenced-by-count":119,"title":["Selective Ablation of \u03b2\u2010Galactosidase\u2010Expressing Cells with a Rationally Designed Activatable Photosensitizer"],"prefix":"10.1002","volume":"53","author":[{"given":"Yuki","family":"Ichikawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mako","family":"Kamiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiaki","family":"Obata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Terai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasuku","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenjiro","family":"Hanaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuteru","family":"Urano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,21]]},"reference":[{"key":"e_1_2_2_1_2","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.89"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-10-110"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1204096109"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/cb100431e"},{"key":"e_1_2_2_6_2","unstructured":"\u00a0"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.06.091"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja900443b"},{"key":"e_1_2_2_9_2","unstructured":"\u00a0"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja204781t"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja309688m"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2004.03.029"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja068740g"},{"key":"e_1_2_2_14_2","unstructured":"\u00a0"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(90)90601-5"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(00)00038-1"},{"key":"e_1_2_2_17_2","unstructured":"\u00a0"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.02.007"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-391856-7.00044-5"},{"key":"e_1_2_2_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1008623107"},{"key":"e_1_2_2_21_2","unstructured":"\u00a0"},{"key":"e_1_2_2_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611142104"},{"key":"e_1_2_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.301290"},{"key":"e_1_2_2_24_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-0448"}],"container-title":["Angewandte 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